Transfer of amoxicillin to suckling mink (Neovison vison) kits via the milk from dams treated orally or intra-muscularly

Julie Melsted Birch*, Henrik Lauritz Frandsen, Tina Struve, Jens Frederik Agger, Henrik Elvang Jensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Treatment of mink kits with pre-weaning diarrhea (PWD) can be time-consuming and expensive for the farmer, and the efficacy of the treatment procedure may be questioned. Evidence-based treatment protocols for application on affected animals at farms with outbreaks of PWD are lacking. In Denmark, the dams are sometimes treated with amoxicillin, however, it is unknown if it is passed on to the mink kits via the milk. The aim of the present study was to investigate if amoxicillin is transferred via the milk to the kits after oral (PO) and intramuscular (IM) treatment, respectively, of the dam. Moreover, we estimated the concentrations of amoxicillin continuously in serum from the kits up to 8 h after administration. The concentration of amoxicillin was not affected by the route of administration (P = .64) and serum reached the highest level after 8 h (34 ng/mL, CI95% = [24.3-47.7]). The serum concentrations of amoxicillin in the mink kits achieved within 8 h were judged too low to exert antimicrobial impact on relevant bacterial species.
Original languageEnglish
JournalResearch in Veterinary Science
Pages (from-to)47-50
Publication statusPublished - 2019


  • Intra-muscular
  • Lactation period
  • Oral
  • Pharmacokinetics
  • Pre-weaning diarrhea
  • Sticky kits


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