Transcriptomics of immature rat testes from chemically induced hypothyroid rats reveal shared and compound-specific effects

Ida S.W. Strand*, Monica K. Draskau, Louise Ramhøj, Marta Axelstad, Bertrand Evrard, Frédéric Chalmel, Terje Svingen

*Corresponding author for this work

Research output: Contribution to conferencePosterResearch

Abstract

Developmental hypothyroidism can affect testicular growth in rodents and humans. For example, rats exposed perinatally to the antithyroid drug propylthiouracil (PTU), which reduces thyroid hormones (THs) by inhibiting the thyroperoxidase (TPO) enzyme, display reduction in testes size. Similarly, we observed smaller testes in rats exposed perinatally to two other TPO-inhibiting chemicals: the pharmaceutical methimazole (MMI) and the pesticide amitrole (Ami). However, on closer histopathological examination and analysis of serum hormone levels, the effects on the testes were different between the two chemicals (see poster Draskau et al). This suggests different effects beyond hypothyroidism; thus, by further analysis we can start unravelling how hypothyroidism disrupts testis development at the molecular level concomitantly with additional endocrine disrupting effects by environmental chemicals. To investigate the transcriptional profile of rat testicles, we employed bulk-RNA-barcoding and sequencing (BRB-seq) of postnatal rat testicles after perinatal exposure to MMI and amitrole.
Original languageEnglish
Publication date2023
Number of pages1
Publication statusPublished - 2023
Event22nd European Testis Workshop - Caux Palace, Montreux, Switzerland
Duration: 18 Jun 202322 Jun 2023
Conference number: 22
https://etw2023.org/

Conference

Conference22nd European Testis Workshop
Number22
LocationCaux Palace
Country/TerritorySwitzerland
CityMontreux
Period18/06/202322/06/2023
Internet address

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