Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

Henry Cope; Jonas Elsborg; Samuel Demharter; J. Tyson McDonald; Chiara Wernecke; Hari Parthasarathy; Hriday Unadkat; Mira Chatrathi; Jennifer Claudio; Sigrid Reinsch; Pinar Avci; Sara R. Zwart; Scott M. Smith; Martina Heer; Masafumi Muratani; Cem Meydan; Eliah Overbey; Jangkeun Kim; Christopher R. Chin; Jiwoon Park; Jonathan C. Schisler; Christopher E. Mason; Nathaniel J. Szewczyk; Craig R. G. Willis; Amr Salam; Afshin Beheshti

doi:10.1038/s43856-024-00532-9

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

Henry Cope, Jonas Elsborg, Samuel Demharter, J. Tyson McDonald, Chiara Wernecke, Hari Parthasarathy, Hriday Unadkat, Mira Chatrathi, Jennifer Claudio, Sigrid Reinsch, Pinar Avci, Sara R. Zwart, Scott M. Smith, Martina Heer, Masafumi Muratani, Cem Meydan, Eliah Overbey, Jangkeun Kim, Christopher R. Chin, Jiwoon ParkJonathan C. Schisler, Christopher E. Mason, Nathaniel J. Szewczyk, Craig R. G. Willis, Amr Salam, Afshin Beheshti^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Background: Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood.
Methods: To address this issue, we used a systems biology approach utilizing NASA's Open Science Data Repository (OSDR) on space flown murine transcriptomic datasets focused on the skin, biochemical profiles of 50 NASA astronauts and human transcriptomic datasets generated from blood and hair samples of JAXA astronauts, as well as blood samples obtained from the NASA Twins Study, and skin and blood samples from the first civilian commercial mission, Inspiration4.
Results: Key biological changes related to skin health, DNA damage & repair, and mitochondrial dysregulation are identified as potential drivers for skin health risks during spaceflight. Additionally, a machine learning model is utilized to determine gene pairings associated with spaceflight response in the skin. While we identified spaceflight-induced dysregulation, such as alterations in genes associated with skin barrier function and collagen formation, our results also highlight the remarkable ability for organisms to re-adapt back to Earth via post-flight re-tuning of gene expression.
Conclusion: Our findings can guide future research on developing countermeasures for mitigating spaceflight-associated skin damage.

Original language	English
Article number	106
Journal	Communications Medicine
Volume	4
Issue number	1
Number of pages	18
ISSN	2730-664X
DOIs	https://doi.org/10.1038/s43856-024-00532-9
Publication status	Published - 2024

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Cope, H., Elsborg, J., Demharter, S., McDonald, J. T., Wernecke, C., Parthasarathy, H., Unadkat, H., Chatrathi, M., Claudio, J., Reinsch, S., Avci, P., Zwart, S. R., Smith, S. M., Heer, M., Muratani, M., Meydan, C., Overbey, E., Kim, J., Chin, C. R., ... Beheshti, A. (2024). Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology. Communications Medicine, 4(1), Article 106. https://doi.org/10.1038/s43856-024-00532-9

@article{bedb42d24fc74d80a65224e83800e5a7,

title = "Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology",

abstract = "Background: Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood. Methods: To address this issue, we used a systems biology approach utilizing NASA's Open Science Data Repository (OSDR) on space flown murine transcriptomic datasets focused on the skin, biochemical profiles of 50 NASA astronauts and human transcriptomic datasets generated from blood and hair samples of JAXA astronauts, as well as blood samples obtained from the NASA Twins Study, and skin and blood samples from the first civilian commercial mission, Inspiration4. Results: Key biological changes related to skin health, DNA damage & repair, and mitochondrial dysregulation are identified as potential drivers for skin health risks during spaceflight. Additionally, a machine learning model is utilized to determine gene pairings associated with spaceflight response in the skin. While we identified spaceflight-induced dysregulation, such as alterations in genes associated with skin barrier function and collagen formation, our results also highlight the remarkable ability for organisms to re-adapt back to Earth via post-flight re-tuning of gene expression. Conclusion: Our findings can guide future research on developing countermeasures for mitigating spaceflight-associated skin damage.",

author = "Henry Cope and Jonas Elsborg and Samuel Demharter and McDonald, {J. Tyson} and Chiara Wernecke and Hari Parthasarathy and Hriday Unadkat and Mira Chatrathi and Jennifer Claudio and Sigrid Reinsch and Pinar Avci and Zwart, {Sara R.} and Smith, {Scott M.} and Martina Heer and Masafumi Muratani and Cem Meydan and Eliah Overbey and Jangkeun Kim and Chin, {Christopher R.} and Jiwoon Park and Schisler, {Jonathan C.} and Mason, {Christopher E.} and Szewczyk, {Nathaniel J.} and Willis, {Craig R. G.} and Amr Salam and Afshin Beheshti",

year = "2024",

doi = "10.1038/s43856-024-00532-9",

language = "English",

volume = "4",

journal = "Communications Medicine",

issn = "2730-664X",

publisher = "Nature",

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Cope, H, Elsborg, J, Demharter, S, McDonald, JT, Wernecke, C, Parthasarathy, H, Unadkat, H, Chatrathi, M, Claudio, J, Reinsch, S, Avci, P, Zwart, SR, Smith, SM, Heer, M, Muratani, M, Meydan, C, Overbey, E, Kim, J, Chin, CR, Park, J, Schisler, JC, Mason, CE, Szewczyk, NJ, Willis, CRG, Salam, A & Beheshti, A 2024, 'Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology', Communications Medicine, vol. 4, no. 1, 106. https://doi.org/10.1038/s43856-024-00532-9

TY - JOUR

T1 - Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

AU - Cope, Henry

AU - Elsborg, Jonas

AU - Demharter, Samuel

AU - McDonald, J. Tyson

AU - Wernecke, Chiara

AU - Parthasarathy, Hari

AU - Unadkat, Hriday

AU - Chatrathi, Mira

AU - Claudio, Jennifer

AU - Reinsch, Sigrid

AU - Avci, Pinar

AU - Zwart, Sara R.

AU - Smith, Scott M.

AU - Heer, Martina

AU - Muratani, Masafumi

AU - Meydan, Cem

AU - Overbey, Eliah

AU - Kim, Jangkeun

AU - Chin, Christopher R.

AU - Park, Jiwoon

AU - Schisler, Jonathan C.

AU - Mason, Christopher E.

AU - Szewczyk, Nathaniel J.

AU - Willis, Craig R. G.

AU - Salam, Amr

AU - Beheshti, Afshin

PY - 2024

Y1 - 2024

N2 - Background: Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood. Methods: To address this issue, we used a systems biology approach utilizing NASA's Open Science Data Repository (OSDR) on space flown murine transcriptomic datasets focused on the skin, biochemical profiles of 50 NASA astronauts and human transcriptomic datasets generated from blood and hair samples of JAXA astronauts, as well as blood samples obtained from the NASA Twins Study, and skin and blood samples from the first civilian commercial mission, Inspiration4. Results: Key biological changes related to skin health, DNA damage & repair, and mitochondrial dysregulation are identified as potential drivers for skin health risks during spaceflight. Additionally, a machine learning model is utilized to determine gene pairings associated with spaceflight response in the skin. While we identified spaceflight-induced dysregulation, such as alterations in genes associated with skin barrier function and collagen formation, our results also highlight the remarkable ability for organisms to re-adapt back to Earth via post-flight re-tuning of gene expression. Conclusion: Our findings can guide future research on developing countermeasures for mitigating spaceflight-associated skin damage.

AB - Background: Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood. Methods: To address this issue, we used a systems biology approach utilizing NASA's Open Science Data Repository (OSDR) on space flown murine transcriptomic datasets focused on the skin, biochemical profiles of 50 NASA astronauts and human transcriptomic datasets generated from blood and hair samples of JAXA astronauts, as well as blood samples obtained from the NASA Twins Study, and skin and blood samples from the first civilian commercial mission, Inspiration4. Results: Key biological changes related to skin health, DNA damage & repair, and mitochondrial dysregulation are identified as potential drivers for skin health risks during spaceflight. Additionally, a machine learning model is utilized to determine gene pairings associated with spaceflight response in the skin. While we identified spaceflight-induced dysregulation, such as alterations in genes associated with skin barrier function and collagen formation, our results also highlight the remarkable ability for organisms to re-adapt back to Earth via post-flight re-tuning of gene expression. Conclusion: Our findings can guide future research on developing countermeasures for mitigating spaceflight-associated skin damage.

U2 - 10.1038/s43856-024-00532-9

DO - 10.1038/s43856-024-00532-9

M3 - Journal article

C2 - 38862781

SN - 2730-664X

VL - 4

JO - Communications Medicine

JF - Communications Medicine

IS - 1

M1 - 106

ER -

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

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