Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons

Rasmus Larsen, Sacha A. F. T. van Hijum, Jan Martinussen, Oscar P. Kuipers, Jan Kok

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In previous studies, we have shown that direct protein-protein. interaction between the two regulators ArgR and AhrC in Lactococcus lactis is required for arginine-dependent repression of the biosynthetic argC promoter and the activation of the catabolic arcA promoter. Here, we establish the global ArgR and AhrC regulons by transcriptome analyses and show that both regulators are dedicated to the control of arginine metabolism in L. lactis.
    Original languageEnglish
    JournalApplied and Environmental Microbiology
    Volume74
    Issue number15
    Pages (from-to)4768-4771
    ISSN0099-2240
    DOIs
    Publication statusPublished - 2008

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