Transcription and the aspect ratio of DNA: Paper

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Abstract

Two separate regimes exist for the aspect ratio of DNA. A low aspect regime where DNA will twist further under strain and a high aspect regime where DNA will untwist under strain. The question of the overall geometry, i.e. the aspect ratio, of DNA is revisited from the perspective of a geometrical analysis of transcription. It is shown that under certain reasonable assumptions transcription is only possible if the aspect ratio is in the regime corresponding to further twisting. We find this constraint to be in agreement with long-established crystallographic studies of DNA.
Original languageEnglish
Article number093008
JournalNew Journal of Physics
Volume15
Issue number9
ISSN1367-2630
DOIs
Publication statusPublished - 2013

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