Transcranial brain stimulation: closing the loop between brain and stimulation

Anke Karabanov, Axel Thielscher, Hartwig Roman Siebner

    Research output: Contribution to journalJournal articleResearchpeer-review

    441 Downloads (Pure)


    PURPOSE OF REVIEW: To discuss recent strategies for boosting the efficacy of noninvasive transcranial brain stimulation to improve human brain function. RECENT FINDINGS: Recent research exposed substantial intra- and inter-individual variability in response to plasticity-inducing transcranial brain stimulation. Trait-related and state-related determinants contribute to this variability, challenging the standard approach to apply stimulation in a rigid, one-size-fits-all fashion. Several strategies have been identified to reduce variability and maximize the plasticity-inducing effects of noninvasive transcranial brain stimulation. Priming interventions or paired associative stimulation can be used to ‘standardize’ the brain-state and hereby, homogenize the group response to stimulation. Neuroanatomical and neurochemical profiling based on magnetic resonance imaging and spectroscopy can capture trait-related and state-related variability. Fluctuations in brain-states can be traced online with functional brain imaging and inform the timing or other settings of transcranial brain stimulation. State-informed open-loop stimulation is aligned to the expression of a predefined brain state, according to prespecified rules. In contrast, adaptive closed-loop stimulation dynamically adjusts stimulation settings based on the occurrence of stimulation-induced state changes. SUMMARY: Approaches that take into account trait-related and state-related determinants of stimulation-induced plasticity bear considerable potential to establish noninvasive transcranial brain stimulation as interventional therapeutic tool.
    Original languageEnglish
    JournalCurrent Opinion in Neurology
    Issue number4
    Pages (from-to)397-404
    Number of pages8
    Publication statusPublished - 2016


    • Neurology (clinical)
    • Neurology


    Dive into the research topics of 'Transcranial brain stimulation: closing the loop between brain and stimulation'. Together they form a unique fingerprint.

    Cite this