Abstract
Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.
Original language | English |
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Title of host publication | 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI) |
Publisher | IEEE |
Publication date | 2013 |
Pages | 1288-1291 |
ISBN (Print) | 978-1-4673-6456-0 |
DOIs | |
Publication status | Published - 2013 |
Event | 2013 IEEE International Symposium on Biomedical Imaging - San Francisco, United States Duration: 7 Apr 2013 → 11 Apr 2013 Conference number: 10 |
Conference
Conference | 2013 IEEE International Symposium on Biomedical Imaging |
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Number | 10 |
Country/Territory | United States |
City | San Francisco |
Period | 07/04/2013 → 11/04/2013 |
Series | International Symposium on Biomedical Imaging. Proceedings |
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ISSN | 1945-7928 |
Keywords
- Analytical models
- Diseases
- Educational institutions
- Imaging
- Manifolds
- Principal component analysis
- Tensile stress
- Continuous Medial Representation
- Diffusion MRI
- Multiple Sclerosis
- White Matter Atlas