Tract-oriented statistical group comparison of diffusion in sheet-like white matter

Mark Lyksborg, T. B. Dyrby, P. S. Sorensen, M. Blinkenberg, H. R. Siebner, D. Alexander, Rasmus Larsen, H. Zhang

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Abstract

Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.
Original languageEnglish
Title of host publication2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI)
PublisherIEEE
Publication date2013
Pages1288-1291
ISBN (Print)978-1-4673-6456-0
DOIs
Publication statusPublished - 2013
Event10th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - San Francisco, United States
Duration: 7 Apr 201311 Apr 2013
http://www.biomedicalimaging.org/2013/
http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=20048

Conference

Conference10th IEEE International Symposium on Biomedical Imaging
CountryUnited States
CitySan Francisco
Period07/04/201311/04/2013
Internet address
SeriesInternational Symposium on Biomedical Imaging. Proceedings
ISSN1945-7928

Keywords

  • Analytical models
  • Diseases
  • Educational institutions
  • Imaging
  • Manifolds
  • Principal component analysis
  • Tensile stress
  • Continuous Medial Representation
  • Diffusion MRI
  • Multiple Sclerosis
  • White Matter Atlas

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