Tract-oriented statistical group comparison of diffusion in sheet-like white matter

Mark Lyksborg; T. B. Dyrby; P. S. Sorensen; M. Blinkenberg; H. R. Siebner; D. Alexander; Rasmus Larsen; H. Zhang

doi:10.1109/ISBI.2013.6556767

Tract-oriented statistical group comparison of diffusion in sheet-like white matter

Mark Lyksborg, T. B. Dyrby, P. S. Sorensen, M. Blinkenberg, H. R. Siebner, D. Alexander, Rasmus Larsen, H. Zhang

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.

Original language	English
Title of host publication	2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI)
Publisher	IEEE
Publication date	2013
Pages	1288-1291
ISBN (Print)	978-1-4673-6456-0
DOIs	https://doi.org/10.1109/ISBI.2013.6556767
Publication status	Published - 2013
Event	10th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - San Francisco, United States Duration: 7 Apr 2013 → 11 Apr 2013 http://www.biomedicalimaging.org/2013/ http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=20048

Conference

Conference	10th IEEE International Symposium on Biomedical Imaging
Country/Territory	United States
City	San Francisco
Period	07/04/2013 → 11/04/2013
Internet address	http://www.biomedicalimaging.org/2013/ http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=20048

Series	International Symposium on Biomedical Imaging. Proceedings
ISSN	1945-7928

Keywords

Analytical models
Diseases
Educational institutions
Imaging
Manifolds
Principal component analysis
Tensile stress
Continuous Medial Representation
Diffusion MRI
Multiple Sclerosis
White Matter Atlas

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10.1109/ISBI.2013.6556767

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Lyksborg, M., Dyrby, T. B., Sorensen, P. S., Blinkenberg, M., Siebner, H. R., Alexander, D., Larsen, R., & Zhang, H. (2013). Tract-oriented statistical group comparison of diffusion in sheet-like white matter. In 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI) (pp. 1288-1291). IEEE. International Symposium on Biomedical Imaging. Proceedings https://doi.org/10.1109/ISBI.2013.6556767

Lyksborg, Mark ; Dyrby, T. B. ; Sorensen, P. S. ; Blinkenberg, M. ; Siebner, H. R. ; Alexander, D. ; Larsen, Rasmus ; Zhang, H. / Tract-oriented statistical group comparison of diffusion in sheet-like white matter. 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI). IEEE, 2013. pp. 1288-1291 (International Symposium on Biomedical Imaging. Proceedings).

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abstract = "Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.",

keywords = "Analytical models, Diseases, Educational institutions, Imaging, Manifolds, Principal component analysis, Tensile stress, Continuous Medial Representation, Diffusion MRI, Multiple Sclerosis, White Matter Atlas",

author = "Mark Lyksborg and Dyrby, {T. B.} and Sorensen, {P. S.} and M. Blinkenberg and Siebner, {H. R.} and D. Alexander and Rasmus Larsen and H. Zhang",

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doi = "10.1109/ISBI.2013.6556767",

language = "English",

isbn = "978-1-4673-6456-0",

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booktitle = "2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI)",

publisher = "IEEE",

address = "United States",

note = "10th IEEE International Symposium on Biomedical Imaging : From Nano to Macro, ISBI 2013 ; Conference date: 07-04-2013 Through 11-04-2013",

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Lyksborg, M, Dyrby, TB, Sorensen, PS, Blinkenberg, M, Siebner, HR, Alexander, D, Larsen, R & Zhang, H 2013, Tract-oriented statistical group comparison of diffusion in sheet-like white matter. in 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI). IEEE, International Symposium on Biomedical Imaging. Proceedings, pp. 1288-1291, 10th IEEE International Symposium on Biomedical Imaging, San Francisco, California, United States, 07/04/2013. https://doi.org/10.1109/ISBI.2013.6556767

Tract-oriented statistical group comparison of diffusion in sheet-like white matter. / Lyksborg, Mark; Dyrby, T. B.; Sorensen, P. S.; Blinkenberg, M.; Siebner, H. R.; Alexander, D.; Larsen, Rasmus; Zhang, H.

2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI). IEEE, 2013. p. 1288-1291 (International Symposium on Biomedical Imaging. Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AU - Lyksborg, Mark

AU - Dyrby, T. B.

AU - Sorensen, P. S.

AU - Blinkenberg, M.

AU - Siebner, H. R.

AU - Alexander, D.

AU - Larsen, Rasmus

AU - Zhang, H.

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N2 - Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.

AB - Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.

KW - Analytical models

KW - Diseases

KW - Educational institutions

KW - Imaging

KW - Manifolds

KW - Principal component analysis

KW - Tensile stress

KW - Continuous Medial Representation

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KW - Multiple Sclerosis

KW - White Matter Atlas

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M3 - Article in proceedings

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T3 - International Symposium on Biomedical Imaging. Proceedings

SP - 1288

EP - 1291

BT - 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI)

PB - IEEE

T2 - 10th IEEE International Symposium on Biomedical Imaging

Y2 - 7 April 2013 through 11 April 2013

ER -

Tract-oriented statistical group comparison of diffusion in sheet-like white matter

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