Tract-oriented statistical group comparison of diffusion in sheet-like white matter

Mark Lyksborg, T. B. Dyrby, P. S. Sorensen, M. Blinkenberg, H. R. Siebner, D. Alexander, Rasmus Larsen, H. Zhang

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Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.
Original languageEnglish
Title of host publication2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI)
Publication date2013
ISBN (Print)978-1-4673-6456-0
Publication statusPublished - 2013
Event2013 IEEE International Symposium on Biomedical Imaging - San Francisco, United States
Duration: 7 Apr 201311 Apr 2013
Conference number: 10


Conference2013 IEEE International Symposium on Biomedical Imaging
Country/TerritoryUnited States
CitySan Francisco
SeriesInternational Symposium on Biomedical Imaging. Proceedings


  • Analytical models
  • Diseases
  • Educational institutions
  • Imaging
  • Manifolds
  • Principal component analysis
  • Tensile stress
  • Continuous Medial Representation
  • Diffusion MRI
  • Multiple Sclerosis
  • White Matter Atlas


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