Abstract
A broadly useful acid-labile traceless azido linker for the solid-phase synthesis of NH-1,2,3-triazoles is presented. A variety of alkynes were efficiently immobilized on a range of polymeric supports by Cu(I)-mediated azide-alkyne cycloadditions. Supported triazoles showed excellent compatibility with subsequent peptide chemistry. Release of pure material (typically >95%) from the solid support was readily achieved by treatment with aqueous TFA.
Original language | English |
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Journal | Organic Letters |
Volume | 12 |
Issue number | 23 |
Pages (from-to) | 5414-5417 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2010 |