Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions

K. Gustafsson, E. Wattrang, C. Fossum, Peter M. H. Heegaard, Peter Lind, A. Uggla

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    As already reported, the mountain hare is much more susceptible than the domestic rabbit to oral inoculation with Toxoplasma gondii, as judged by pathological changes and dissemination of parasites within the body. In the present paper, further interspecies variations are reported. Concentrations of the acute phase reactant haptoglobin were raised in hares but not in rabbits one week post-infection (pi), probably reflecting the severe tissue damage present. No difference in the early humoral immune response of hares and rabbits was found, both species producing IgM and IgG antibodies to T. gondii one week pi. Lymphocyte stimulation tests performed before and one week after inoculation showed a high proliferative response to the parasite in blood cell cultures from rabbits but not hares. The fatal outcome of T. gondii infection in the hares is probably due, at least in part, to the lack of cellular response.
    Original languageEnglish
    JournalJournal of Comparative Pathology
    Volume117
    Issue number4
    Pages (from-to)361-369
    ISSN0021-9975
    DOIs
    Publication statusPublished - 1997

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