Toxin synergism in snake venoms

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    Abstract

    Synergism between venom toxins exists for a range of snake species. Synergism can be derived from both intermolecular interactions and supramolecular interactions between venom components, and can be the result of toxins targeting the same protein, biochemical pathway or physiological process. Few simple systematic tools and methods for determining the presence of synergism exist, but include co-administration of venom components and assessment of Accumulated Toxicity Scores. A better understanding of how to investigate synergism in snake venoms may help unravel strategies for developing novel therapies against snakebite envenoming by elucidating mechanisms for toxicity and interactions between venom components.
    Original languageEnglish
    JournalToxin Reviews
    Volume35
    Issue number3-4
    Pages (from-to)165-170
    Number of pages6
    ISSN1556-9543
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Accumulated toxicity score
    • Intermolecular synergism
    • Snake toxins
    • Snake venom
    • Supramolecular synergism
    • Toxicity score
    • Toxin synergism

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