Toxicity of pristine and paint-embedded TiO2 nanomaterials

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

DOI

  • Author: Saber, A. T.

    National Research Centre for the Working Environment, Denmark

  • Author: Mortensen, A.

    National Research Centre for the Working Environment, Denmark

  • Author: Szarek, J.

    University of Warmia and Mazury in Olsztyn, Poland

  • Author: Jacobsen, N. R.

    National Research Centre for the Working Environment, Denmark

  • Author: Levin, M.

    National Research Centre for the Working Environment, Denmark

  • Author: Koponen, I. K.

    National Research Centre for the Working Environment, Denmark

  • Author: Jensen, K. A.

    National Research Centre for the Working Environment, Denmark

  • Author: Vogel, U.

    Department of Health Technology, Technical University of Denmark

  • Author: Wallin, H.

    National Research Centre for the Working Environment, Denmark

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Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 mu g of TiO2NMs or 54, 162 and 486 mu g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.
Original languageEnglish
JournalHuman & Experimental Toxicology
Volume38
Issue number1
Pages (from-to)11-24
ISSN0960-3271
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • DNA damage, Nanomaterial, Inflammation, Intratracheal instillation, Nano alkyd paint, Paint dust, Sanding dust, Titanium dioxide

ID: 166662644