Toxicity of pristine and paint-embedded TiO2 nanomaterials

A.T. Saber*, A. Mortensen, J. Szarek, N. R. Jacobsen, M. Levin, I. K. Koponen, K. A. Jensen, U. Vogel, H. Wallin

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 mu g of TiO2NMs or 54, 162 and 486 mu g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.
Original languageEnglish
JournalHuman & Experimental Toxicology
Volume38
Issue number1
Pages (from-to)11-24
ISSN0960-3271
DOIs
Publication statusPublished - 2019

Keywords

  • DNA damage
  • Nanomaterial
  • Inflammation
  • Intratracheal instillation
  • Nano alkyd paint
  • Paint dust
  • Sanding dust
  • Titanium dioxide

Cite this

Saber, A. T., Mortensen, A., Szarek, J., Jacobsen, N. R., Levin, M., Koponen, I. K., ... Wallin, H. (2019). Toxicity of pristine and paint-embedded TiO2 nanomaterials. Human & Experimental Toxicology, 38(1), 11-24. https://doi.org/10.1177/0960327118774910
Saber, A.T. ; Mortensen, A. ; Szarek, J. ; Jacobsen, N. R. ; Levin, M. ; Koponen, I. K. ; Jensen, K. A. ; Vogel, U. ; Wallin, H. / Toxicity of pristine and paint-embedded TiO2 nanomaterials. In: Human & Experimental Toxicology. 2019 ; Vol. 38, No. 1. pp. 11-24.
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abstract = "Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 mu g of TiO2NMs or 54, 162 and 486 mu g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.",
keywords = "DNA damage, Nanomaterial, Inflammation, Intratracheal instillation, Nano alkyd paint, Paint dust, Sanding dust, Titanium dioxide",
author = "A.T. Saber and A. Mortensen and J. Szarek and Jacobsen, {N. R.} and M. Levin and Koponen, {I. K.} and Jensen, {K. A.} and U. Vogel and H. Wallin",
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Saber, AT, Mortensen, A, Szarek, J, Jacobsen, NR, Levin, M, Koponen, IK, Jensen, KA, Vogel, U & Wallin, H 2019, 'Toxicity of pristine and paint-embedded TiO2 nanomaterials', Human & Experimental Toxicology, vol. 38, no. 1, pp. 11-24. https://doi.org/10.1177/0960327118774910

Toxicity of pristine and paint-embedded TiO2 nanomaterials. / Saber, A.T.; Mortensen, A.; Szarek, J.; Jacobsen, N. R.; Levin, M.; Koponen, I. K.; Jensen, K. A.; Vogel, U.; Wallin, H.

In: Human & Experimental Toxicology, Vol. 38, No. 1, 2019, p. 11-24.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Toxicity of pristine and paint-embedded TiO2 nanomaterials

AU - Saber, A.T.

AU - Mortensen, A.

AU - Szarek, J.

AU - Jacobsen, N. R.

AU - Levin, M.

AU - Koponen, I. K.

AU - Jensen, K. A.

AU - Vogel, U.

AU - Wallin, H.

PY - 2019

Y1 - 2019

N2 - Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 mu g of TiO2NMs or 54, 162 and 486 mu g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.

AB - Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 mu g of TiO2NMs or 54, 162 and 486 mu g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.

KW - DNA damage

KW - Nanomaterial

KW - Inflammation

KW - Intratracheal instillation

KW - Nano alkyd paint

KW - Paint dust

KW - Sanding dust

KW - Titanium dioxide

U2 - 10.1177/0960327118774910

DO - 10.1177/0960327118774910

M3 - Journal article

VL - 38

SP - 11

EP - 24

JO - Human & Experimental Toxicology

JF - Human & Experimental Toxicology

SN - 0960-3271

IS - 1

ER -

Saber AT, Mortensen A, Szarek J, Jacobsen NR, Levin M, Koponen IK et al. Toxicity of pristine and paint-embedded TiO2 nanomaterials. Human & Experimental Toxicology. 2019;38(1):11-24. https://doi.org/10.1177/0960327118774910