Towards the Synthesis of Diverse Types of Carrageenan Oligosaccharides

Christine Kinnaert, Mads Hartvig Clausen

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Abstract

Carrageenans are a family of linear sulfated polysaccharides that are extracted from red seaweeds.They play important roles in the biology of algae and furthermore they have many important industrial applications, such as gelling agent in the food industry. The idealized structures of the 10 known types of carrageenans are presented in Figure 1. The carrageenans are intriguing structures: they have a backbone of D-galactose with alternating β-1,4 and α-1,3 bonds with varying degree of sulfation of the 2, 6, 2’ and 4’-positions. Upon treatment with alkali, an 1,3-anhydrogalactose is formed and the α-linked galactose residues undergo a conformational change from 4C1 to 1C4 which increases thegelling property of the molecule. We wish to synthesize well-defined oligocarrageenans. Our synthetic strategy aims at producing all ten types of carrageenans from a single precursor carrying different protecting groups that can be cleaved specifically to introduce the sulfate groups at various positions depending on the targeted carrageenan.
Original languageEnglish
Publication date2017
Publication statusPublished - 2017
Event19th European Carbohydrate Symposium - CCIB, Barcelona, Spain
Duration: 2 Jul 20176 Jul 2017
Conference number: 19

Conference

Conference19th European Carbohydrate Symposium
Number19
LocationCCIB
CountrySpain
CityBarcelona
Period02/07/201706/07/2017

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