Towards the mid-infrared optical biopsy

Angela B. Seddon, Trevor M. Benson, Slawomir Sujecki, Nabil Abdel-Moneim, Zhuoqi Tang, David Furniss, Lukasz Sojka, Nick Stone, Nallala Jayakrupakar, Gavin Rhys Lloyd, Ian Lindsay, Jon Ward, Mark Farries, Peter M. Moselund, Bruce Napier, Samir Lamrini, Uffe Visbech Møller, Irnis Kubat, Christian Rosenberg Petersen, Ole Bang

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the mid-infrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy ('opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR-infrared spectroscopy for improVed medical diAgnostics (317803;
Original languageEnglish
Title of host publicationProceedings of SPIE
PublisherSPIE - International Society for Optical Engineering
Publication date2016
Article number970302
Publication statusPublished - 2016
EventOptical Biopsy XIV - The Moscone Center, San Francisco, United States
Duration: 15 Feb 201617 Feb 2016


ConferenceOptical Biopsy XIV
LocationThe Moscone Center
CountryUnited States
CitySan Francisco
SeriesProceedings of S P I E - International Society for Optical Engineering


  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology, Nuclear Medicine and Imaging
  • Biomedical imaging
  • Cancer diagnosis
  • Chalcogenide-glass fibreoptics
  • Mid-infrared
  • Supercontinuum generation
  • Biopsy
  • Chemical industry
  • Cost effectiveness
  • Diagnosis
  • Diseases
  • Energy efficiency
  • Fibers
  • Mapping
  • Medical imaging
  • Molecular imaging
  • Near infrared spectroscopy
  • Optical fibers
  • Photomapping
  • Surgery
  • Chalcogenide glass
  • Disruptive technology
  • High numerical apertures
  • Mid-infrared detection
  • Mid-infrared spectral regions
  • Midinfrared
  • Infrared devices
  • IR
  • biomedical imaging
  • supercontinuum generation
  • chalcogenide-glass fibreoptics
  • cancer diagnosis
  • Optical and laser radiation (medical uses)
  • Fibre optic sensors; fibre gyros
  • Patient diagnostic methods and instrumentation
  • Optical and laser radiation (biomedical imaging/measurement)
  • Fibre optic sensors
  • biomedical optical imaging
  • cancer
  • endoscopes
  • fibre optic sensors
  • chemical processing
  • manufacturing
  • midinfrared molecular mapping
  • medical fiber-based systems
  • midinfrared wideband source
  • active midinfrared fiber broadband supercontinuum
  • high-numerical aperture midinfrared optical fiber
  • passive midinfrared optical fibers
  • real-time diagnosis
  • surgery
  • in vivo medical diagnostics
  • midinfrared spectral region
  • midinfrared molecular sensing
  • midinfrared optical biopsy

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