Towards the mid-infrared optical biopsy

Angela B. Seddon; Trevor M. Benson; Slawomir Sujecki; Nabil Abdel-Moneim; Zhuoqi Tang; David Furniss; Lukasz Sojka; Nick Stone; Nallala Jayakrupakar; Gavin Rhys Lloyd; Ian Lindsay; Jon Ward; Mark Farries; Peter M. Moselund; Bruce Napier; Samir Lamrini; Uffe Visbech Møller; Irnis Kubat; Christian Rosenberg Petersen; Ole Bang

doi:10.1117/12.2211584

Towards the mid-infrared optical biopsy

Angela B. Seddon, Trevor M. Benson, Slawomir Sujecki, Nabil Abdel-Moneim, Zhuoqi Tang, David Furniss, Lukasz Sojka, Nick Stone, Nallala Jayakrupakar, Gavin Rhys Lloyd, Ian Lindsay, Jon Ward, Mark Farries, Peter M. Moselund, Bruce Napier, Samir Lamrini, Uffe Visbech Møller, Irnis Kubat, Christian Rosenberg Petersen, Ole Bang

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the mid-infrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy ('opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR-infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).

Original language	English
Title of host publication	Proceedings of SPIE
Volume	9703
Publisher	SPIE - International Society for Optical Engineering
Publication date	2016
Article number	970302
DOIs	https://doi.org/10.1117/12.2211584
Publication status	Published - 2016
Event	SPIE Photonics West BiOS 2016 - The Moscone Center, San Francisco, United States Duration: 13 Feb 2016 → 17 Feb 2016 http://spie.org/conferences-and-exhibitions/photonics-west

Conference

Conference	SPIE Photonics West BiOS 2016
Location	The Moscone Center
Country/Territory	United States
City	San Francisco
Period	13/02/2016 → 17/02/2016
Internet address	http://spie.org/conferences-and-exhibitions/photonics-west

Series	Proceedings of SPIE - The International Society for Optical Engineering
ISSN	0277-786X

Keywords

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology, Nuclear Medicine and Imaging
Biomedical imaging
Cancer diagnosis
Chalcogenide-glass fibreoptics
Mid-infrared
Supercontinuum generation
Biopsy
Chemical industry
Cost effectiveness
Diagnosis
Diseases
Energy efficiency
Fibers
Mapping
Medical imaging
Molecular imaging
Near infrared spectroscopy
Optical fibers
Photomapping
Surgery
Chalcogenide glass
Disruptive technology
High numerical apertures
Mid-infrared detection
Mid-infrared spectral regions
Midinfrared
Infrared devices
OPTICS
RADIOLOGY,
CHALCOGENIDE GLASS-FIBER
STEP-INDEX FIBER
INFRARED-SPECTROSCOPY
SUPERCONTINUUM SOURCE
IR
LIGHT
POWER
biomedical imaging
supercontinuum generation
chalcogenide-glass fibreoptics
cancer diagnosis
Optical and laser radiation (medical uses)
Fibre optic sensors; fibre gyros
Patient diagnostic methods and instrumentation
Optical and laser radiation (biomedical imaging/measurement)
Fibre optic sensors
biomedical optical imaging
cancer
endoscopes
fibre optic sensors
chemical processing
manufacturing
midinfrared molecular mapping
medical fiber-based systems
midinfrared wideband source
active midinfrared fiber broadband supercontinuum
high-numerical aperture midinfrared optical fiber
passive midinfrared optical fibers
real-time diagnosis
surgery
in vivo medical diagnostics
midinfrared spectral region
midinfrared molecular sensing
midinfrared optical biopsy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.2211584

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Seddon, A. B., Benson, T. M., Sujecki, S., Abdel-Moneim, N., Tang, Z., Furniss, D., Sojka, L., Stone, N., Jayakrupakar, N., Lloyd, G. R., Lindsay, I., Ward, J., Farries, M., Moselund, P. M., Napier, B., Lamrini, S., Møller, U. V., Kubat, I., Petersen, C. R., & Bang, O. (2016). Towards the mid-infrared optical biopsy. In Proceedings of SPIE (Vol. 9703). Article 970302 SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2211584

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abstract = "We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the mid-infrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy ('opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR-infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).",

keywords = "Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Biomaterials, Radiology, Nuclear Medicine and Imaging, Biomedical imaging, Cancer diagnosis, Chalcogenide-glass fibreoptics, Mid-infrared, Supercontinuum generation, Biopsy, Chemical industry, Cost effectiveness, Diagnosis, Diseases, Energy efficiency, Fibers, Mapping, Medical imaging, Molecular imaging, Near infrared spectroscopy, Optical fibers, Photomapping, Surgery, Chalcogenide glass, Disruptive technology, High numerical apertures, Mid-infrared detection, Mid-infrared spectral regions, Midinfrared, Infrared devices, OPTICS, RADIOLOGY,, CHALCOGENIDE GLASS-FIBER, STEP-INDEX FIBER, INFRARED-SPECTROSCOPY, SUPERCONTINUUM SOURCE, IR, LIGHT, POWER, biomedical imaging, supercontinuum generation, chalcogenide-glass fibreoptics, cancer diagnosis, Optical and laser radiation (medical uses), Fibre optic sensors; fibre gyros, Patient diagnostic methods and instrumentation, Optical and laser radiation (biomedical imaging/measurement), Fibre optic sensors, biomedical optical imaging, cancer, endoscopes, fibre optic sensors, chemical processing, manufacturing, midinfrared molecular mapping, medical fiber-based systems, midinfrared wideband source, active midinfrared fiber broadband supercontinuum, high-numerical aperture midinfrared optical fiber, passive midinfrared optical fibers, real-time diagnosis, surgery, in vivo medical diagnostics, midinfrared spectral region, midinfrared molecular sensing, midinfrared optical biopsy",

author = "Seddon, {Angela B.} and Benson, {Trevor M.} and Slawomir Sujecki and Nabil Abdel-Moneim and Zhuoqi Tang and David Furniss and Lukasz Sojka and Nick Stone and Nallala Jayakrupakar and Lloyd, {Gavin Rhys} and Ian Lindsay and Jon Ward and Mark Farries and Moselund, {Peter M.} and Bruce Napier and Samir Lamrini and M{\o}ller, {Uffe Visbech} and Irnis Kubat and Petersen, {Christian Rosenberg} and Ole Bang",

year = "2016",

doi = "10.1117/12.2211584",

language = "English",

volume = "9703",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE - International Society for Optical Engineering",

booktitle = "Proceedings of SPIE",

note = "SPIE Photonics West BiOS 2016 ; Conference date: 13-02-2016 Through 17-02-2016",

url = "http://spie.org/conferences-and-exhibitions/photonics-west",

}

Seddon, AB, Benson, TM, Sujecki, S, Abdel-Moneim, N, Tang, Z, Furniss, D, Sojka, L, Stone, N, Jayakrupakar, N, Lloyd, GR, Lindsay, I, Ward, J, Farries, M, Moselund, PM, Napier, B, Lamrini, S, Møller, UV, Kubat, I, Petersen, CR & Bang, O 2016, Towards the mid-infrared optical biopsy. in Proceedings of SPIE. vol. 9703, 970302, SPIE - International Society for Optical Engineering, Proceedings of SPIE - The International Society for Optical Engineering, SPIE Photonics West BiOS 2016, San Francisco, California, United States, 13/02/2016. https://doi.org/10.1117/12.2211584

Towards the mid-infrared optical biopsy. / Seddon, Angela B.; Benson, Trevor M.; Sujecki, Slawomir et al.
Proceedings of SPIE. Vol. 9703 SPIE - International Society for Optical Engineering, 2016. 970302 (Proceedings of SPIE - The International Society for Optical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Towards the mid-infrared optical biopsy

AU - Seddon, Angela B.

AU - Benson, Trevor M.

AU - Sujecki, Slawomir

AU - Abdel-Moneim, Nabil

AU - Tang, Zhuoqi

AU - Furniss, David

AU - Sojka, Lukasz

AU - Stone, Nick

AU - Jayakrupakar, Nallala

AU - Lloyd, Gavin Rhys

AU - Lindsay, Ian

AU - Ward, Jon

AU - Farries, Mark

AU - Moselund, Peter M.

AU - Napier, Bruce

AU - Lamrini, Samir

AU - Møller, Uffe Visbech

AU - Kubat, Irnis

AU - Petersen, Christian Rosenberg

AU - Bang, Ole

PY - 2016

Y1 - 2016

N2 - We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the mid-infrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy ('opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR-infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).

AB - We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the mid-infrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy ('opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR-infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).

KW - Atomic and Molecular Physics, and Optics

KW - Electronic, Optical and Magnetic Materials

KW - Biomaterials

KW - Radiology, Nuclear Medicine and Imaging

KW - Biomedical imaging

KW - Cancer diagnosis

KW - Chalcogenide-glass fibreoptics

KW - Mid-infrared

KW - Supercontinuum generation

KW - Biopsy

KW - Chemical industry

KW - Cost effectiveness

KW - Diagnosis

KW - Diseases

KW - Energy efficiency

KW - Fibers

KW - Mapping

KW - Medical imaging

KW - Molecular imaging

KW - Near infrared spectroscopy

KW - Optical fibers

KW - Photomapping

KW - Surgery

KW - Chalcogenide glass

KW - Disruptive technology

KW - High numerical apertures

KW - Mid-infrared detection

KW - Mid-infrared spectral regions

KW - Midinfrared

KW - Infrared devices

KW - OPTICS

KW - RADIOLOGY,

KW - CHALCOGENIDE GLASS-FIBER

KW - STEP-INDEX FIBER

KW - INFRARED-SPECTROSCOPY

KW - SUPERCONTINUUM SOURCE

KW - IR

KW - LIGHT

KW - POWER

KW - biomedical imaging

KW - supercontinuum generation

KW - chalcogenide-glass fibreoptics

KW - cancer diagnosis

KW - Optical and laser radiation (medical uses)

KW - Fibre optic sensors; fibre gyros

KW - Patient diagnostic methods and instrumentation

KW - Optical and laser radiation (biomedical imaging/measurement)

KW - Fibre optic sensors

KW - biomedical optical imaging

KW - cancer

KW - endoscopes

KW - fibre optic sensors

KW - chemical processing

KW - manufacturing

KW - midinfrared molecular mapping

KW - medical fiber-based systems

KW - midinfrared wideband source

KW - active midinfrared fiber broadband supercontinuum

KW - high-numerical aperture midinfrared optical fiber

KW - passive midinfrared optical fibers

KW - real-time diagnosis

KW - surgery

KW - in vivo medical diagnostics

KW - midinfrared spectral region

KW - midinfrared molecular sensing

KW - midinfrared optical biopsy

U2 - 10.1117/12.2211584

DO - 10.1117/12.2211584

M3 - Article in proceedings

VL - 9703

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Proceedings of SPIE

PB - SPIE - International Society for Optical Engineering

T2 - SPIE Photonics West BiOS 2016

Y2 - 13 February 2016 through 17 February 2016

ER -

Towards the mid-infrared optical biopsy

Abstract

Conference

Keywords

UN SDGs

Access to Document

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