Towards supercontinuum-driven hyperspectral microscopy in the mid-infrared

I. D. Lindsay, S. Valle, J. Ward, G. Stevens, M. Farries, Laurent Huot, C. Brooks, Peter M. Moselund, R. M. Vinella, M. Abdalla, D. de Gaspari, R. M. von Wurtemberg, S. Smuk, H. Martijn, J. Nallala, N. Stone, C. Barta, R. Hasal, Uffe Visbech Møller, Ole BangS. Sujecki, A. Seddon

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

The extension of supercontinuum (SC) sources into the mid-infrared, via the use of fluoride and chalcogenide optical fibers, potentially offers the high radiance of a laser combined with spectral coverage far exceeding that of typical tunable lasers and comparable to traditional black-body emitters. Together with advances in mid-IR imaging detectors and novel tunable filter designs, such supercontinua hold considerable potential as sources of illumination for spectrally-resolved microscopy targeting applications such as rapid histological screening. The ability to rapidly and arbitrarily select particular wavelengths of interest from a broad emission spectrum, covering a wide range of biologically relevant targets, lends itself to image acquisition only at key relevant wavelengths leading to more manageable datasets. However, in addition to offering new imaging modalities, SC sources also present a range of challenges to successful integration with typical spectral microscopy instrumentation, including appropriate utilisation of their high spatial coherence. In this paper the application of SC sources to spectrally-resolved microscopy in the mid-IR is discussed and systems-integration considerations specific to these sources highlighted. Preliminary results in the 3-5 mu m region, obtained within the European FP7 project MINERVA, are also presented here.
Original languageEnglish
Title of host publicationProceedings of SPIE
Number of pages9
Volume9703
PublisherSPIE - International Society for Optical Engineering
Publication date2016
Pages970304
Article number970304
DOIs
Publication statusPublished - 2016
EventOptical Biopsy XIV - The Moscone Center, San Francisco, United States
Duration: 15 Feb 201617 Feb 2016

Conference

ConferenceOptical Biopsy XIV
LocationThe Moscone Center
CountryUnited States
CitySan Francisco
Period15/02/201617/02/2016
SeriesProceedings of S P I E - International Society for Optical Engineering
Volume9703
ISSN0277-786X

Keywords

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology, Nuclear Medicine and Imaging
  • AOTF
  • FTIR
  • Imaging
  • Microscope
  • Mid-infrared
  • Spectroscopy
  • Supercontinuum
  • Synchrotron
  • Biopsy
  • Emission spectroscopy
  • Image acquisition
  • Imaging techniques
  • Infrared devices
  • Infrared imaging
  • Microscopes
  • Optical fibers
  • Synchrotrons
  • Chalcogenide optical fibers
  • Emission spectrums
  • Midinfrared
  • Spectral microscopies
  • Super continuum
  • Systems integration
  • Fourier transform infrared spectroscopy
  • OPTICS
  • RADIOLOGY,
  • MULTIPLE SYNCHROTRON BEAMS
  • INFRARED-SPECTROSCOPY
  • GENERATION
  • supercontinuum
  • mid-infrared
  • microscope
  • spectroscopy
  • imaging
  • synchrotron
  • Optical and laser radiation (medical uses)
  • Patient diagnostic methods and instrumentation
  • Optical microscopy
  • Optical and laser radiation (biomedical imaging/measurement)
  • Nonlinear optics and devices
  • Fibre optics
  • biological tissues
  • biomedical optical imaging
  • hyperspectral imaging
  • infrared imaging
  • laser tuning
  • optical fibres
  • optical microscopy
  • supercontinuum generation
  • MINERVA
  • European FP7 project
  • spatial coherence
  • spectral microscopy instrumentation
  • SC sources
  • image acquisition
  • broad emission spectrum
  • rapid histological screening
  • spectrally-resolved microscopy targeting applications
  • illumination
  • tunable filter designs
  • midinfrared imaging detectors
  • traditional black-body emitters
  • tunable lasers
  • spectral coverage
  • chalcogenide optical fibers
  • fluoride optical fibers
  • supercontinuum sources
  • supercontinuum-driven hyperspectral microscopy
  • wavelength 3 mum to 5 mum

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