Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA

Gavrielle R. Untracht, Madeleine S. Durkee, Mei Zhao, Andrew Kwok-Cheung Lam, Bartosz L. Sikorski, Marinko V. Sarunic, Peter E. Andersen, David D. Sampson, Fred K. Chen, Danuta M. Sampson*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

5 Downloads (Pure)

Abstract

Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment of ocular and systemic diseases. However, the OCTA user community lacks universal and transparent image analysis tools that can be applied to images from a range of OCTA instruments and provide reliable and consistent microvascular metrics from diverse datasets. We present a retinal extension to the OCTA Vascular Analyser (OCTAVA) that addresses the challenges of providing robust, easy-to-use, and transparent analysis of retinal OCTA images. OCTAVA is a user-friendly, open-source toolbox that can analyse retinal OCTA images from various instruments. The toolbox delivers seven microvascular metrics for the whole image or subregions and six metrics characterising the foveal avascular zone. We validate OCTAVA using images collected by four commercial OCTA instruments demonstrating robust performance across datasets from different instruments acquired at different sites from different study cohorts. We show that OCTAVA delivers values for retinal microvascular metrics comparable to the literature and reduces their variation between studies compared to their commercial equivalents. By making OCTAVA publicly available, we aim to expand standardised research and thereby improve the reproducibility of quantitative analysis of retinal microvascular imaging. Such improvements will help to better identify more reliable and sensitive biomarkers of ocular and systemic diseases.

Original languageEnglish
Article number5979
JournalScientific Reports
Volume14
Issue number1
Number of pages15
ISSN2045-2322
DOIs
Publication statusPublished - 2024

Fingerprint

Dive into the research topics of 'Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA'. Together they form a unique fingerprint.

Cite this