Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

Carina L Gargalo, Isuru Udugama, Katrin Pontius, Pau C. Lopez, Rasmus F. Nielsen, Aliyeh Hasanzadeh, Seyed Soheil Mansouri, Christoph Bayer, Helena Junicke, Krist V. Gernaey*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. However, many biomanufacturing companies, especially in the biopharma sector, still have a long way to go to fully benefit from smart manufacturing as they first need to transition their current operations to an information-driven future. One of the most significant obstacles towards the implementation of smart biomanufacturing is the collection of large sets of relevant data. Therefore, in this work, we both summarize the advances that have been made to date with regards to the monitoring and control of bioprocesses, and highlight some of the key technologies that have the potential to contribute to gathering big data. Empowering the current biomanufacturing industry to transition to Industry 4.0 operations allows for improved productivity through information-driven automation, not only by developing infrastructure, but also by introducing more advanced monitoring and control strategies.
Original languageEnglish
JournalJournal of Industrial Microbiology and Biotechnology
Volume47
Pages (from-to)947–964
ISSN1367-5435
DOIs
Publication statusPublished - 2020

Keywords

  • Bioprocesses
  • Industry 4.0
  • Big data
  • Control
  • Sensors
  • Smart biomanufacturing

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