In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.
|Conference||Label-free Biomedical Imaging and Sensing 2019|
|Location||The Moscone Center|
|Period||07/02/2019 → 07/02/2019|
|Series||Proceedings of SPIE, the International Society for Optical Engineering|
- Multispectral photoacoustic spectroscopy
- Supercontinuum lasers
- Glucose monitoring