Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime

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Abstract

In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.
Original languageEnglish
Title of host publicationProceedings of SPIE
Number of pages7
Volume10890
PublisherSPIE - International Society for Optical Engineering
Publication date2019
Article number108900W
DOIs
Publication statusPublished - 2019
EventLabel-free Biomedical Imaging and Sensing 2019 - The Moscone Center, San Francisco, United States
Duration: 7 Feb 20197 Feb 2019

Conference

ConferenceLabel-free Biomedical Imaging and Sensing 2019
LocationThe Moscone Center
CountryUnited States
CitySan Francisco
Period07/02/201907/02/2019
SeriesProceedings of SPIE, the International Society for Optical Engineering
Volume10890
ISSN0277-786X

Keywords

  • Multispectral photoacoustic spectroscopy
  • Supercontinuum lasers
  • Glucose monitoring

Cite this

Dasa, M. K., Markos, C., Janting, J., Adamu, A. I., Bowen, P., & Bang, O. (2019). Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. In Proceedings of SPIE (Vol. 10890). [108900W] SPIE - International Society for Optical Engineering. Proceedings of SPIE, the International Society for Optical Engineering, Vol.. 10890 https://doi.org/10.1117/12.2510284