Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime

Manoj Kumar Dasa; Christos Markos; Jakob Janting; Abubakar Isa Adamu; Patrick  Bowen; Ole Bang

doi:10.1117/12.2510284

Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime

Manoj Kumar Dasa, Christos Markos, Jakob Janting, Abubakar Isa Adamu, Patrick Bowen, Ole Bang

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

247 Downloads (Pure)

Abstract

In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.

Original language	English
Title of host publication	Proceedings of SPIE
Number of pages	7
Volume	10890
Publisher	SPIE - International Society for Optical Engineering
Publication date	2019
Article number	108900W
DOIs	https://doi.org/10.1117/12.2510284
Publication status	Published - 2019
Event	Label-free Biomedical Imaging and Sensing 2019 - The Moscone Center, San Francisco, United States Duration: 7 Feb 2019 → 7 Feb 2019

Conference

Conference	Label-free Biomedical Imaging and Sensing 2019
Location	The Moscone Center
Country	United States
City	San Francisco
Period	07/02/2019 → 07/02/2019

Series	Proceedings of SPIE, the International Society for Optical Engineering
Volume	10890
ISSN	0277-786X

Keywords

Multispectral photoacoustic spectroscopy
Supercontinuum lasers
Glucose monitoring

Access to Document

10.1117/12.2510284

108900WFinal published version, 664 KB

Cite this

Dasa, M. K., Markos, C., Janting, J., Adamu, A. I., Bowen, P., & Bang, O. (2019). Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. In Proceedings of SPIE (Vol. 10890). [108900W] SPIE - International Society for Optical Engineering. Proceedings of SPIE, the International Society for Optical Engineering, Vol.. 10890 https://doi.org/10.1117/12.2510284

Dasa, Manoj Kumar ; Markos, Christos ; Janting, Jakob ; Adamu, Abubakar Isa ; Bowen, Patrick ; Bang, Ole. / Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. Proceedings of SPIE. Vol. 10890 SPIE - International Society for Optical Engineering, 2019. (Proceedings of SPIE, the International Society for Optical Engineering, Vol. 10890).

@inproceedings{6d1b64add0104757885294215650a568,

title = "Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime",

abstract = "In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.",

keywords = "Multispectral photoacoustic spectroscopy, Supercontinuum lasers, Glucose monitoring",

author = "Dasa, {Manoj Kumar} and Christos Markos and Jakob Janting and Adamu, {Abubakar Isa} and Patrick Bowen and Ole Bang",

year = "2019",

doi = "10.1117/12.2510284",

language = "English",

volume = "10890",

series = "Proceedings of SPIE, the International Society for Optical Engineering",

publisher = "SPIE - International Society for Optical Engineering",

booktitle = "Proceedings of SPIE",

note = "Label-free Biomedical Imaging and Sensing 2019, LBIS 2019 ; Conference date: 07-02-2019 Through 07-02-2019",

}

Dasa, MK , Markos, C , Janting, J , Adamu, AI, Bowen, P & Bang, O 2019, Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. in Proceedings of SPIE. vol. 10890, 108900W, SPIE - International Society for Optical Engineering, Proceedings of SPIE, the International Society for Optical Engineering, vol. 10890, Label-free Biomedical Imaging and Sensing 2019, San Francisco, United States, 07/02/2019. https://doi.org/10.1117/12.2510284

Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. / Dasa, Manoj Kumar ; Markos, Christos ; Janting, Jakob ; Adamu, Abubakar Isa; Bowen, Patrick ; Bang, Ole.

Proceedings of SPIE. Vol. 10890 SPIE - International Society for Optical Engineering, 2019. 108900W (Proceedings of SPIE, the International Society for Optical Engineering, Vol. 10890).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime

AU - Dasa, Manoj Kumar

AU - Markos, Christos

AU - Janting, Jakob

AU - Adamu, Abubakar Isa

AU - Bowen, Patrick

AU - Bang, Ole

PY - 2019

Y1 - 2019

N2 - In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.

AB - In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.

KW - Multispectral photoacoustic spectroscopy

KW - Supercontinuum lasers

KW - Glucose monitoring

U2 - 10.1117/12.2510284

DO - 10.1117/12.2510284

M3 - Article in proceedings

VL - 10890

T3 - Proceedings of SPIE, the International Society for Optical Engineering

BT - Proceedings of SPIE

PB - SPIE - International Society for Optical Engineering

T2 - Label-free Biomedical Imaging and Sensing 2019

Y2 - 7 February 2019 through 7 February 2019

ER -

Dasa MK , Markos C , Janting J , Adamu AI, Bowen P, Bang O. Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime. In Proceedings of SPIE. Vol. 10890. SPIE - International Society for Optical Engineering. 2019. 108900W. (Proceedings of SPIE, the International Society for Optical Engineering, Vol. 10890). https://doi.org/10.1117/12.2510284