Towards a unified multi-scale strategy for bio-manufacturing process development

Thomas Bisgaard, Nima Nazemzadah, Eduardo Krebs Kleingesinds, Negin Yousefi, Christian Beenfeldt, Seyed Soheil Mansouri*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


Biomanufacturing has been increasingly receiving attention in the past few decades due to the need for sustainable production of various consumables, global energy crisis, and climate change. The biomanufacturing sector or the so called biosolution has found application in the production of various products such as fine and bulk chemical, pharmaceuticals, food and feed products, and biofuels. However, this industrial sector is facing a lot of challenges mainly due to scalability issues and lack of fundamental understanding from the process development point of view, which need to be addressed. Hence, a unified systematic multi-scale approach is required to address some of the current challenges by providing profound knowledge of the fundamental phenomena at various scales for a more efficient process scale-up. In this study, a conceptual systematic framework is proposed that incorporated the fundamental knowledge from various disciplines that potentially could tackle some of the aforementioned challenges within the biosolutions framework.
Original languageEnglish
Title of host publicationProceedings of the 33rd European Symposium on Computer Aided Process Engineering
EditorsAntonis Kokossis, Michael C. Georgiadis, Efstratios N. Pistikopoulos
Publication date2023
ISBN (Print)978-0-443-23553-5, 978-0-443-15274-0
Publication statusPublished - 2023
Event33rd European Symposium on Computer Aided Process Engineering - Athens, Greece
Duration: 18 Jun 202321 Jun 2023


Conference33rd European Symposium on Computer Aided Process Engineering
SeriesComputer Aided Chemical Engineering


  • Multi-scale
  • Modelling
  • Scale-up
  • Bioprocess
  • Microalgae


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