Towards a Digital Twin: A validated Digital Model of a Pilot Scale Bioreactor producing Green Fluorescent Protein (GFP)

Ole Laustsen Lave, Carina L. Gargalo, Ryan Barton, Isuru A. Udugama, Krist V. Gernaey*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Industrial scale bio-manufacturing processes are transitioning towards Industry 4.0, which promises to change the competitive landscape. As part of this (r)evolution, there is an increased focus on developing digital twins of critical operations, such as fermentation processes. A key economic driver for the enthusiastic embrace of digital twins by this industry is the promise of increased process efficiencies and resource utilization, mainly through improved plant operations. However, for digital twins to move from the “current hype” to a beneficial solution in the industry, some challenges must be overcome. This manuscript attempts to identify these challenges and opportunities by developing a Digital Model of a Pilot Scale Bioreactor producing Green Fluorescent Protein (GFP) currently used for Teaching purposes.
Original languageEnglish
Title of host publicationProceedings of the 31th European Symposium on Computer Aided Process Engineering (ESCAPE30)
EditorsMetin Türkay, Rafiqul Gani
Place of PublicationAmsterdam
PublisherElsevier
Publication date2021
Pages625-630
ISBN (Electronic)978-0-323-98325-9
DOIs
Publication statusPublished - 2021
Event31st European Symposium on Computer Aided Process Engineering (ESCAPE 31) - Istanbul, Turkey
Duration: 6 Jun 20219 Jun 2021

Conference

Conference31st European Symposium on Computer Aided Process Engineering (ESCAPE 31)
Country/TerritoryTurkey
CityIstanbul
Period06/06/202109/06/2021
SeriesComputer Aided Chemical Engineering
ISSN1570-7946

Keywords

  • Digital Twins
  • Validated models
  • Bioreactors
  • Fermentation

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