Industrial scale bio-manufacturing processes are transitioning towards Industry 4.0, which promises to change the competitive landscape. As part of this (r)evolution, there is an increased focus on developing digital twins of critical operations, such as fermentation processes. A key economic driver for the enthusiastic embrace of digital twins by this industry is the promise of increased process efficiencies and resource utilization, mainly through improved plant operations. However, for digital twins to move from the “current hype” to a beneficial solution in the industry, some challenges must be overcome. This manuscript attempts to identify these challenges and opportunities by developing a Digital Model of a Pilot Scale Bioreactor producing Green Fluorescent Protein (GFP) currently used for Teaching purposes.
|Conference||31st European Symposium on Computer Aided Process Engineering (ESCAPE 31)|
|Period||06/06/2021 → 09/06/2021|
|Series||Computer Aided Chemical Engineering|
- Digital Twins
- Validated models