Abstract
Combining 3-dimensional spherical microtissues and microfluidic technologies lays the foundation for a modular pharmacological platform for drug development, toxicity testing, and investigations of complex compound-tissue interactions. In this contribution, we present the basic concept of our idea and illustrate how simple 3D tissue structures can be integrated in a continuous-perfusion environment by using basic microfluidic structures. First validations have been performed by optical means and by measuring tissue-specific viability markers.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publication date | 2012 |
| Pages | 1540-1542 |
| Publication status | Published - 2012 |
| Externally published | Yes |
| Event | 16th International Conference of Miniaturized Systems for Chemistry and Life Sciences - Okinawa Convention Center, Okinawa, Japan Duration: 28 Oct 2012 → 1 Nov 2012 Conference number: 16 http://www.microtas12.org/ |
Conference
| Conference | 16th International Conference of Miniaturized Systems for Chemistry and Life Sciences |
|---|---|
| Number | 16 |
| Location | Okinawa Convention Center |
| Country/Territory | Japan |
| City | Okinawa |
| Period | 28/10/2012 → 01/11/2012 |
| Internet address |
Keywords
- Body on a chip
- 3D tissue
- Drug development
- Perfusion
- HepG2