Abstract
Mol-scale oxyfunctionalization of cyclohexane to
cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is
reported. Using AaeUPO from Agrocybe aegerita and simple H2O2 as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h–1, approx. 15 g L–1 h–1)
were achieved. Current limitations of the proposed biooxidation system
have been identified paving the way for future improvements and
implementation.
Original language | English |
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Journal | Organic Process Research & Development |
Volume | 27 |
Issue number | 7 |
Pages (from-to) | 1384–1389 |
ISSN | 1083-6160 |
DOIs | |
Publication status | Published - 2023 |
Keywords
- Biocatalysis
- Peroxygenase
- Oxyfunctionalization
- Cyclohexane
- Upscaling
- Bulk chemical