Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane

Thomas Hilberath, Remco van Oosten, Juliet Victoria, Hugo Brasselet, Miguel Alcalde, John M. Woodley, Frank Hollmann*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H2O2 as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h–1, approx. 15 g L–1 h–1) were achieved. Current limitations of the proposed biooxidation system have been identified paving the way for future improvements and implementation.
Original languageEnglish
JournalOrganic Process Research & Development
Volume27
Issue number7
Pages (from-to)1384–1389
ISSN1083-6160
DOIs
Publication statusPublished - 2023

Keywords

  • Biocatalysis
  • Peroxygenase
  • Oxyfunctionalization
  • Cyclohexane
  • Upscaling
  • Bulk chemical

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