Topology optimization for biocatalytic microreactor configurations

Ines Pereira Rosinha, Krist Gernaey, John Woodley, Ulrich Krühne

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


The aim of this study is to present an innovative strategy for selecting a reactor for a specific process. Instead of adapting the process to a well-known reactor shape, a topology optimization method is used to obtain the best reactor configuration, and is applied to a biocatalyic reaction system as a case study. The Evolutionary Structure Optimization (ESO) method is applied using an interface between Matlab® and the computational fluid dynamic simulation software ANSYS CFX®. In the case study, theESO method is applied to optimize the spatial distribution of immobilized enzyme inside a microreactor. The results allow evaluating which regions in the microreactorhave more importance for the product formation. In fact, it was possible to simulate the improvement of the outlet product concentration per same amount of enzyme by modifying the spatial distribution of the immobilized enzyme.
Original languageEnglish
Title of host publicationProceedings of the 25th European Symposium on Computer Aided Process Engineering
EditorsKrist V. Gernaey, Jakob K. Huusom, Rafiqul Gani
Publication date2015
Publication statusPublished - 2015
Event25th European Symposium on Computer Aided Process Engineering : 12th International Symposium on Process Systems Engineering - Copenhagen, Denmark
Duration: 31 May 20154 Jun 2015


Conference25th European Symposium on Computer Aided Process Engineering
Internet address
SeriesComputer Aided Chemical Engineering


  • Topology optimization
  • Biocatalysis
  • Immobilized enzymes
  • CFD


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