Topological principles and developmental algorithms might refine diffusion tractography

Giorgio M. Innocenti*, Tim B. Dyrby, Gabriel Girard, Etienne St-Onge, Jean Philippe Thiran, Alessandro Daducci, Maxime Descoteaux

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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The identification and reconstruction of axonal pathways in the living brain or “ex-vivo” is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural–functional correlates. Unfortunately, the methods suffer from juvenile drawbacks. In this perspective paper we mention several computational and developmental principles, which might stimulate a new generation of algorithms and a discussion bridging the neuroimaging and neuroanatomy communities.

Original languageEnglish
JournalBrain Structure and Function
Issue number1
Pages (from-to)1–8
Publication statusPublished - 15 Jan 2019


  • Axons
  • Brain development
  • Brain pathways
  • Diffusion MRI
  • Tractography


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