TY - JOUR
T1 - Topographical Distribution of Arsenic, Manganese, and Selenium in the Normal Human Brain
AU - Larsen, Niels Agersnap
AU - Pakkenberg, H.
AU - Damsgaard, Else
AU - Heydorn, Kaj
PY - 1979
Y1 - 1979
N2 - The concentrations of arsenic, manganese and selenium per gram wet tissue weight were determined in samples from 24 areas of normal human brains from 5 persons with ages ranging from 15 to 81 years of age. The concentrations of the 3 elements were determined for each sample by means of neutron activation analysis with radiochemical separation. Distinct patterns of distribution were shown for each of the 3 elements. Variations between individuals were found for some but not all brain areas, resulting in coefficients of variation between individuals of about 30% for arsenic, 10% for manganese and 20% for selenium. The results seem to indicate that arsenic is associated with the lipid phase, manganese with the dry matter and selenium with the aqueous phase of brain tissue.
AB - The concentrations of arsenic, manganese and selenium per gram wet tissue weight were determined in samples from 24 areas of normal human brains from 5 persons with ages ranging from 15 to 81 years of age. The concentrations of the 3 elements were determined for each sample by means of neutron activation analysis with radiochemical separation. Distinct patterns of distribution were shown for each of the 3 elements. Variations between individuals were found for some but not all brain areas, resulting in coefficients of variation between individuals of about 30% for arsenic, 10% for manganese and 20% for selenium. The results seem to indicate that arsenic is associated with the lipid phase, manganese with the dry matter and selenium with the aqueous phase of brain tissue.
U2 - 10.1016/0022-510X(79)90173-4
DO - 10.1016/0022-510X(79)90173-4
M3 - Journal article
SN - 0022-510X
VL - 42
SP - 407
EP - 416
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 3
ER -