Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study

Malene Høj Outzen, Anne Tjønneland, David J. Hughes, Mazda Jenab, Kirsten Frederiksen, Lutz Schomburg, Steve Morris, Kim Overvad, Anja Olsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Low selenium status may be associated with increased risk of prostate cancer (PC), particularly aggressive PC, and variation in selenoprotein genes may constitute an important modifying factor. We aimed to investigate the association between two selenium status biomarkers [toenail selenium, plasma selenoprotein P (SELENOP)] and risk of advanced, high-grade and advanced-stage PC. We further studied whether variations in selenoprotein genes were associated with PC risk and selenium biomarker concentrations. In the “Diet, Cancer and Health” cohort, 27 178 men aged 50 to 65 years were enrolled from 1993 to 1997. Between baseline and 2012, 1160 cohort participants were diagnosed with advanced PC; among these 462 had high-grade and 281 had advanced-stage disease at diagnosis. Each case was risk set-matched to one control. Toenail selenium and plasma SELENOP concentrations were measured by neutron activation analysis and a SELENOP-ELISA, respectively, and genotyping was performed for 27 selected single nucleotide polymorphisms (SNPs) in 12 selenium pathway genes (including seven selenoproteins) by allele-specific PCR. Toenail selenium and circulating SELENOP concentrations were not associated with advanced, high-grade or advanced-stage PC. After adjustment for multiple testing, none of the genes were associated with PC risk. Neither toenail selenium nor plasma SELENOP was associated with advanced, high-grade or advanced-stage PC.

Original languageEnglish
JournalInternational Journal of Cancer
Volume148
Issue number4
Pages (from-to)876-883
ISSN0020-7136
DOIs
Publication statusPublished - 2021

Keywords

  • biomarkers
  • nested case-control study
  • prostate cancer
  • selenium
  • single nucleotide polymorphisms

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