Tlr7/8 agonists and liposome compositions

Thomas Lars Andresen; Jonas Rosager Henriksen; Martin Kisha Kraemer

Tlr7/8 agonists and liposome compositions

Thomas Lars Andresen (Inventor)
, Jonas Rosager Henriksen (Inventor)
, Martin Kisha Kraemer (Inventor)

Department of Health Technology

Research output: Patent

37 Downloads (Orbit)

Abstract

The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.

Original language	English
IPC	C07D 413/ 12 A I
Patent number	WO2020023680
Filing date	24/07/2019
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	19/06/2019
Priority number	US201962863352P
Publication status	Published - 30 Jan 2020

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title = "Tlr7/8 agonists and liposome compositions",

abstract = "The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.",

author = "Andresen, \{Thomas Lars\} and Henriksen, \{Jonas Rosager\} and Kraemer, \{Martin Kisha\}",

year = "2020",

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T1 - Tlr7/8 agonists and liposome compositions

AU - Andresen, Thomas Lars

AU - Henriksen, Jonas Rosager

AU - Kraemer, Martin Kisha

PY - 2020/1/30

Y1 - 2020/1/30

N2 - The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.

AB - The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.

M3 - Patent

M1 - WO2020023680

Y2 - 2019/07/24

ER -

Tlr7/8 agonists and liposome compositions

Abstract

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