Abstract
The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.
| Original language | English |
|---|---|
| IPC | C07D 413/ 12 A I |
| Patent number | WO2020023680 |
| Filing date | 24/07/2019 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 19/06/2019 |
| Priority number | US201962863352P |
| Publication status | Published - 30 Jan 2020 |