Tlr7/8 agonists and liposome compositions

Thomas Lars Andresen (Inventor), Jonas Rosager Henriksen (Inventor), Martin Kisha Kraemer (Inventor)

Research output: Patent

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Abstract

The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.

Original languageEnglish
IPCC07D 413/ 12 A I
Patent numberWO2020023680
Filing date24/07/2019
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date19/06/2019
Priority numberUS201962863352P
Publication statusPublished - 30 Jan 2020

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