Abstract
| Original language | English |
|---|---|
| Article number | 1260419 |
| Journal | Science (New York, N.Y.) |
| Volume | 347 |
| Issue number | 6220 |
| Pages (from-to) | 394- |
| Number of pages | 9 |
| ISSN | 0036-8075 |
| DOIs | |
| Publication status | Published - 2015 |
Cite this
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Tissue-based map of the human proteome. / Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina; Asplund, Anna; Olsson, IngMarie; Edlund, Karolina; Lundberg, Emma; Navani, Sanjay; Szigyarto, Cristina Al-Khalili; Odeberg, Jacob; Djureinovic, Dijana; Takanen, Jenny Ottosson; Hober, Sophia; Alm, Tove; Edqvist, Per-Henrik; Berling, Holger; Tegel, Hanna; Mulder, Jan; Rockberg, Johan; Nilsson, Peter; Schwenk, Jochen M.; Hamsten, Marica; von Feilitzen, Kalle; Forsberg, Mattias; Persson, Lukas; Johansson, Fredric; Zwahlen, Martin; von Heijne, Gunnar; Nielsen, Jens; Pontén, Fredrik.
In: Science (New York, N.Y.), Vol. 347, No. 6220, 1260419, 2015, p. 394-.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - Tissue-based map of the human proteome
AU - Uhlén, Mathias
AU - Fagerberg, Linn
AU - Hallström, Björn M.
AU - Lindskog, Cecilia
AU - Oksvold, Per
AU - Mardinoglu, Adil
AU - Sivertsson, Åsa
AU - Kampf, Caroline
AU - Sjöstedt, Evelina
AU - Asplund, Anna
AU - Olsson, IngMarie
AU - Edlund, Karolina
AU - Lundberg, Emma
AU - Navani, Sanjay
AU - Szigyarto, Cristina Al-Khalili
AU - Odeberg, Jacob
AU - Djureinovic, Dijana
AU - Takanen, Jenny Ottosson
AU - Hober, Sophia
AU - Alm, Tove
AU - Edqvist, Per-Henrik
AU - Berling, Holger
AU - Tegel, Hanna
AU - Mulder, Jan
AU - Rockberg, Johan
AU - Nilsson, Peter
AU - Schwenk, Jochen M.
AU - Hamsten, Marica
AU - von Feilitzen, Kalle
AU - Forsberg, Mattias
AU - Persson, Lukas
AU - Johansson, Fredric
AU - Zwahlen, Martin
AU - von Heijne, Gunnar
AU - Nielsen, Jens
AU - Pontén, Fredrik
PY - 2015
Y1 - 2015
N2 - Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
AB - Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
U2 - 10.1126/science.1260419
DO - 10.1126/science.1260419
M3 - Journal article
C2 - 25613900
VL - 347
SP - 394-
JO - Science
JF - Science
SN - 0036-8075
IS - 6220
M1 - 1260419
ER -