Thyroid Nodules in an 11-Year DanThyr Follow-Up Study

Anne Krejbjerg, Lena Bjergved, Inge Bulow Pedersen, Nils Knudsen, Torben Jorgensen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Peter Laurberg

Research output: Contribution to journalJournal articlepeer-review

Abstract

Context: Limited longitudinal data are available on changes in the thyroid gland structure in a population and how this is influenced by iodine fortification (IF). Objective: Our objective was to clarify how IF influenced thyroid gland structure in 2 regions with different iodine intake at baseline (Copenhagen, mild iodine deficiency [ID]; Aalborg, moderate ID). Design and Setting: We conducted a longitudinal population-based study (DanThyr) where participants were examined before (1997) and after (2008) the Danish mandatory IF of salt (2000). Participants: We examined 2465 adults, and ultrasonography was performed by the same sonographers using the same equipment, after controlling performances. Main Outcome Measure: Change in thyroid gland structure was evaluated. Results: The follow-up period saw an increased prevalence of multinodularity (9.8%-13.8%, P
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number12
Pages (from-to)4749-4757
Number of pages9
ISSN0021-972X
DOIs
Publication statusPublished - 2014

Keywords

  • ENDOCRINOLOGY
  • DIFFERENT IODINE STATUS
  • DEFICIENCY
  • ULTRASONOGRAPHY
  • DISORDERS
  • ABNORMALITIES
  • THYROGLOBULIN
  • POPULATIONS
  • PREVALENCE
  • REGIONS
  • VOLUME

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