Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats

Monica K Draskau; Anne-Sofie Ballegaard; Raul Davila; Mikael Pedersen; Louise Ramhøj; Sofie Rising; Ida WS Strand; Cassy M Spiller; Josephine Bowles; Marta Axelstad; Terje Svingen

Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats

Monica K Draskau^*, Anne-Sofie Ballegaard, Raul Davila, Mikael Pedersen, Louise Ramhøj, Sofie Rising, Ida WS Strand, Cassy M Spiller, Josephine Bowles, Marta Axelstad, Terje Svingen

^*Corresponding author for this work

University of Queensland

Research output: Contribution to conference › Poster › Research

Abstract

Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system by e.g. inhibiting the enzyme thyroperoxidase (TPO) and thereby TH production. Low TH levels during development can have adverse effects on the brain, as well as affecting general growth. Hypothyroidism can also affect proliferation of testes cell populations, but in-depth studies on how TH disrupting chemicals can affect testis development are few. Here we show how the TPO inhibitors Amitrole (a pesticide) and methimazole (MMI, a drug) disrupt perinatal testis development in rats, with the most pronounced effect on the germ cell population.

Original language	English
Publication date	2023
Number of pages	1
Publication status	Published - 2023
Event	22nd European Testis Workshop - Caux Palace, Montreux, Switzerland Duration: 18 Jun 2023 → 22 Jun 2023 Conference number: 22 https://etw2023.org/

Conference

Conference	22nd European Testis Workshop
Number	22
Location	Caux Palace
Country/Territory	Switzerland
City	Montreux
Period	18/06/2023 → 22/06/2023
Internet address	https://etw2023.org/

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title = "Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats",

abstract = "Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system by e.g. inhibiting the enzyme thyroperoxidase (TPO) and thereby TH production. Low TH levels during development can have adverse effects on the brain, as well as affecting general growth. Hypothyroidism can also affect proliferation of testes cell populations, but in-depth studies on how TH disrupting chemicals can affect testis development are few. Here we show how the TPO inhibitors Amitrole (a pesticide) and methimazole (MMI, a drug) disrupt perinatal testis development in rats, with the most pronounced effect on the germ cell population.",

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T1 - Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats

AU - Draskau, Monica K

AU - Ballegaard, Anne-Sofie

AU - Davila, Raul

AU - Pedersen, Mikael

AU - Ramhøj, Louise

AU - Rising, Sofie

AU - Strand, Ida WS

AU - Spiller, Cassy M

AU - Bowles, Josephine

AU - Axelstad, Marta

AU - Svingen, Terje

N1 - Conference code: 22

PY - 2023

Y1 - 2023

N2 - Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system by e.g. inhibiting the enzyme thyroperoxidase (TPO) and thereby TH production. Low TH levels during development can have adverse effects on the brain, as well as affecting general growth. Hypothyroidism can also affect proliferation of testes cell populations, but in-depth studies on how TH disrupting chemicals can affect testis development are few. Here we show how the TPO inhibitors Amitrole (a pesticide) and methimazole (MMI, a drug) disrupt perinatal testis development in rats, with the most pronounced effect on the germ cell population.

AB - Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system by e.g. inhibiting the enzyme thyroperoxidase (TPO) and thereby TH production. Low TH levels during development can have adverse effects on the brain, as well as affecting general growth. Hypothyroidism can also affect proliferation of testes cell populations, but in-depth studies on how TH disrupting chemicals can affect testis development are few. Here we show how the TPO inhibitors Amitrole (a pesticide) and methimazole (MMI, a drug) disrupt perinatal testis development in rats, with the most pronounced effect on the germ cell population.

M3 - Poster

T2 - 22nd European Testis Workshop

Y2 - 18 June 2023 through 22 June 2023

ER -

Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats

Abstract

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