Thyroid hormone disruptors methimazole and amitrole perturb testis development in rats

Monica K Draskau*, Anne-Sofie Ballegaard, Raul Davila, Mikael Pedersen, Louise Ramhøj, Sofie Rising, Ida WS Strand, Cassy M Spiller, Josephine Bowles, Marta Axelstad, Terje Svingen

*Corresponding author for this work

Research output: Contribution to conferencePosterResearch

Abstract

Endocrine disrupting chemicals (EDCs) can interfere with the thyroid hormone (TH) system by e.g. inhibiting the enzyme thyroperoxidase (TPO) and thereby TH production. Low TH levels during development can have adverse effects on the brain, as well as affecting general growth. Hypothyroidism can also affect proliferation of testes cell populations, but in-depth studies on how TH disrupting chemicals can affect testis development are few. Here we show how the TPO inhibitors Amitrole (a pesticide) and methimazole (MMI, a drug) disrupt perinatal testis development in rats, with the most pronounced effect on the germ cell population.
Original languageEnglish
Publication date2023
Number of pages1
Publication statusPublished - 2023
Event22nd European Testis Workshop - Caux Palace, Montreux, Switzerland
Duration: 18 Jun 202322 Jun 2023
Conference number: 22
https://etw2023.org/

Conference

Conference22nd European Testis Workshop
Number22
LocationCaux Palace
Country/TerritorySwitzerland
CityMontreux
Period18/06/202322/06/2023
Internet address

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