Thyroglobulin as a marker of iodine nutrition status in the general population

P. Vejbjerg, N. Knudsen, H. Perrild, P. Laurberg, A. Carlé, I. B. Pedersen, Lone Banke Rasmussen

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Abstract

Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P
Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume161
Pages (from-to)475-481
ISSN0804-4643
DOIs
Publication statusPublished - 2009

Cite this

Vejbjerg, P., Knudsen, N., Perrild, H., Laurberg, P., Carlé, A., Pedersen, I. B., & Rasmussen, L. B. (2009). Thyroglobulin as a marker of iodine nutrition status in the general population. European Journal of Endocrinology, 161, 475-481. https://doi.org/10.1530/EJE-09-0262