Thyroglobulin as a marker of iodine nutrition status in the general population

P. Vejbjerg; N. Knudsen; H. Perrild; P. Laurberg; A. Carlé; I. B. Pedersen; Lone Banke Rasmussen

doi:10.1530/EJE-09-0262

Thyroglobulin as a marker of iodine nutrition status in the general population

P. Vejbjerg, N. Knudsen, H. Perrild, P. Laurberg, A. Carlé, I. B. Pedersen, Lone Banke Rasmussen

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P

Original language	English
Journal	European Journal of Endocrinology
Volume	161
Pages (from-to)	475-481
ISSN	0804-4643
DOIs	https://doi.org/10.1530/EJE-09-0262
Publication status	Published - 2009

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title = "Thyroglobulin as a marker of iodine nutrition status in the general population",

abstract = "Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P",

author = "P. Vejbjerg and N. Knudsen and H. Perrild and P. Laurberg and A. Carl{\'e} and Pedersen, {I. B.} and Rasmussen, {Lone Banke}",

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doi = "10.1530/EJE-09-0262",

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TY - JOUR

T1 - Thyroglobulin as a marker of iodine nutrition status in the general population

AU - Vejbjerg, P.

AU - Knudsen, N.

AU - Perrild, H.

AU - Laurberg, P.

AU - Carlé, A.

AU - Pedersen, I. B.

AU - Rasmussen, Lone Banke

PY - 2009

Y1 - 2009

N2 - Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P

AB - Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P

U2 - 10.1530/EJE-09-0262

DO - 10.1530/EJE-09-0262

M3 - Journal article

C2 - 19556382

SN - 0804-4643

VL - 161

SP - 475

EP - 481

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

ER -

Thyroglobulin as a marker of iodine nutrition status in the general population

Abstract

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