Thyroglobulin as a marker of iodine nutrition status in the general population

P. Vejbjerg, N. Knudsen, H. Perrild, P. Laurberg, A. Carlé, I. B. Pedersen, Lone Banke Rasmussen

Research output: Contribution to journalJournal articleResearchpeer-review


Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P
Original languageEnglish
JournalEuropean Journal of Endocrinology
Pages (from-to)475-481
Publication statusPublished - 2009


Dive into the research topics of 'Thyroglobulin as a marker of iodine nutrition status in the general population'. Together they form a unique fingerprint.

Cite this