Thymidine kinases in archaea

A.R. Clausen, A. Matakos, Michael Sandrini, Jure Piskur

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.
    Original languageEnglish
    JournalNucleosides Nucleotides & Nucleic Acids
    Volume25
    Issue number9-11
    Pages (from-to)1159-1163
    ISSN1525-7770
    Publication statusPublished - 2006

    Keywords

    • salvage pathway
    • deoxyribonucleosides kinase
    • archaea
    • thymidine kinase
    • evolution

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