Thymidine kinase diversity in bacteria

Michael Sandrini, A.R. Clausen, B. Munch-Petersen, Jure Piskur

    Research output: Contribution to journalJournal articleResearchpeer-review


    Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
    Original languageEnglish
    JournalNucleosides Nucleotides & Nucleic Acids
    Issue number9-11
    Pages (from-to)1153-1158
    Publication statusPublished - 2006


    • nucleic acids precursors
    • nucleosides
    • pyrimidines
    • deoxyribonucleoside kinase
    • thymidine kinase
    • evolution

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