Thymidine kinase diversity in bacteria

Michael Sandrini; A.R. Clausen; B. Munch-Petersen; Jure Piskur

Thymidine kinase diversity in bacteria

Michael Sandrini, A.R. Clausen, B. Munch-Petersen, Jure Piskur

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

Original language	English
Journal	Nucleosides Nucleotides & Nucleic Acids
Volume	25
Issue number	9-11
Pages (from-to)	1153-1158
ISSN	1525-7770
Publication status	Published - 2006

Keywords

nucleic acids precursors
nucleosides
pyrimidines
deoxyribonucleoside kinase
thymidine kinase
evolution

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Cite this

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T1 - Thymidine kinase diversity in bacteria

AU - Sandrini, Michael

AU - Clausen, A.R.

AU - Munch-Petersen, B.

AU - Piskur, Jure

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Y1 - 2006

N2 - Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

AB - Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

KW - nucleic acids precursors

KW - nucleosides

KW - pyrimidines

KW - deoxyribonucleoside kinase

KW - thymidine kinase

KW - evolution

M3 - Journal article

SN - 1525-7770

VL - 25

SP - 1153

EP - 1158

JO - Nucleosides Nucleotides & Nucleic Acids

JF - Nucleosides Nucleotides & Nucleic Acids

IS - 9-11

ER -