Thymidine kinase diversity in bacteria

Michael Sandrini, A.R. Clausen, B. Munch-Petersen, Jure Piskur

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
    Original languageEnglish
    JournalNucleosides Nucleotides & Nucleic Acids
    Volume25
    Issue number9-11
    Pages (from-to)1153-1158
    ISSN1525-7770
    Publication statusPublished - 2006

    Keywords

    • nucleic acids precursors
    • nucleosides
    • pyrimidines
    • deoxyribonucleoside kinase
    • thymidine kinase
    • evolution

    Cite this

    Sandrini, M., Clausen, A. R., Munch-Petersen, B., & Piskur, J. (2006). Thymidine kinase diversity in bacteria. Nucleosides Nucleotides & Nucleic Acids, 25(9-11), 1153-1158.