Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor

Valeria Josa, Marcin Krzystanek, Tamas Vass, Tamas Lang, Viktoria Juhasz, Kamilla Szilagyi, Balazs Tihanyi, Laszlo Harsanyi, Zoltan Imre Szallasi, Ferenc Salamon, Zsolt Baranyai

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    There is increasing evidence that thrombocytosis is associated with tumor invasion and metastasis formation. It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to evaluate preoperative thrombocytosis as a potential prognostic biomarker in isolated metastases, in patients with liver metastasis of colorectal cancer (mCRC). Clinicopathological data of 166 patients with mCRC who had surgical resection between 2001 and 2011 were collected retrospectively. All primary tumors have been already resected. The platelet count was evaluated based on the standard preoperative blood profile. The patients were followed-up on average for 28 months. Overall survival (OS) of patients with thrombocytosis was significantly worse both in univariate (HR = 3.00, p = 0.03) and in multivariate analysis (HR = 4.68, p = 0.056) when adjusted for gender, age, tumor size and surgical margin. Thrombocytosis was also a good prognosticator of disease-free survival (DFS) with HR = 2.7, p = 0.018 and nearly significant in multivariate setting (HR = 2.26, p = 0.073). The platelet count is a valuable prognostic marker for the survival in patients with mCRC.
    Original languageEnglish
    JournalPathology and Oncology Research
    Volume21
    Issue number4
    Pages (from-to)991-997
    Number of pages7
    ISSN1219-4956
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Thrombocytosis
    • Liver metastasis of colorectal cancer
    • Prognostic factor
    • Survival

    Cite this

    Josa, V., Krzystanek, M., Vass, T., Lang, T., Juhasz, V., Szilagyi, K., Tihanyi, B., Harsanyi, L., Szallasi, Z. I., Salamon, F., & Baranyai, Z. (2015). Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor. Pathology and Oncology Research, 21(4), 991-997. https://doi.org/10.1007/s12253-015-9925-8