Three-dimensional MRI-linac intra-fraction guidance using multiple orthogonal cine-MRI planes

Troels Bjerre, Sjoerd Crijns, Per Munck af Rosenschöld, Marianne Aznar, Lena Specht, Rasmus Larsen, Paul Keall

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The introduction of integrated MRI-radiation therapy systems will offer live intra-fraction imaging. We propose a feasible low-latency multi-plane MRI-linac guidance strategy. In this work we demonstrate how interleaved acquired, orthogonal cine-MRI planes can be used for low-latency tracking of the 3D trajectory of a soft-tissue target structure. The proposed strategy relies on acquiring a pre-treatment 3D breath-hold scan, extracting a 3D target template and performing template matching between this 3D template and pairs of orthogonal 2D cine-MRI planes intersecting the target motion path. For a 60 s free-breathing series of orthogonal cine-MRI planes, we demonstrate that the method was capable of accurately tracking the respiration related 3D motion of the left kidney. Quantitative evaluation of the method using a dataset designed for this purpose revealed a translational error of 1.15 mm for a translation of 39.9 mm. We have demonstrated how interleaved acquired, orthogonal cine-MRI planes can be used for online tracking of soft-tissue target volumes.
Original languageEnglish
JournalPhysics in Medicine and Biology
Volume58
Issue number14
Pages (from-to)4943-4950
ISSN0031-9155
DOIs
Publication statusPublished - 2013

Bibliographical note

Online supplementary data available from stacks.iop.org/PMB/58/4943/mmedia.

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