Three-dimensional accelerated acquisition for hyperpolarized 13C MR with blipped stack-of-spirals and conjugate-gradient SENSE

Rie B. Olin, Juan Diego Sanchez, Rolf F. Schulte, Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Christoffer Laustsen, Lars G. Hanson, Jan H. Ardenkjær-Larsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: To test a new parallel imaging strategy for acceleration of hyperpolarized 13C MR acquisitions based on a 3D blipped-stack-of-spirals trajectory and conjugate gradient SENSE reconstruction with pre-calibrated sensitivities.
Methods: The blipped-stack-of-spirals trajectory was developed for an acceleration factor of four, based on an undersampled stack-of-spirals with gradient blips during spiral readout. The trajectory was developed with volumetric coverage of a large FOV and with high spatial resolution. High temporal resolution was attained through spectral-spatial excitation and four excitations per volume. The blipped-stack-of-spirals was evaluated in simulations and phantom experiments. Next, the method was evaluated for kidney and cardiac imaging in two separate healthy pigs.
Results: Simulation and phantom results showed successful acquisition and reconstruction, but also revealed reconstruction challenges for certain locations and for wide signal sources. For the kidney experiment, the accelerated acquisition showed high similarity to two separately acquired fully sampled datasets with matched spatial and temporal resolution, respectively. For the kidney experiment, the accelerated acquisition proved able to map each metabolite in three dimensions within a single cardiac cycle.
Conclusion: The proposed method demonstrated effective mapping of metabolism in both kidneys and heart of healthy pigs. Limitations seen in phantom experiments, may be irrelevant for most clinical applications, but should be kept in mind as well as reconstruction challenges related to residual aliasing. All in all, we show that the blipped-stack-of-spirals is a relevant parallel imaging method for hyperpolarized human imaging, facilitating better insights into metabolism compared to nonaccelerated acquisition.
Original languageEnglish
JournalMagnetic Resonance in Medicine
ISSN0740-3194
Publication statusAccepted/In press - 2020

Keywords

  • Hyperpolarization
  • 13C MRI
  • Parallel Imaging
  • Metabolic imaging
  • 3D imaging

Cite this

@article{5a43e29ae47b484aaadea7d6b404bf8c,
title = "Three-dimensional accelerated acquisition for hyperpolarized 13C MR with blipped stack-of-spirals and conjugate-gradient SENSE",
abstract = "Purpose: To test a new parallel imaging strategy for acceleration of hyperpolarized 13C MR acquisitions based on a 3D blipped-stack-of-spirals trajectory and conjugate gradient SENSE reconstruction with pre-calibrated sensitivities.Methods: The blipped-stack-of-spirals trajectory was developed for an acceleration factor of four, based on an undersampled stack-of-spirals with gradient blips during spiral readout. The trajectory was developed with volumetric coverage of a large FOV and with high spatial resolution. High temporal resolution was attained through spectral-spatial excitation and four excitations per volume. The blipped-stack-of-spirals was evaluated in simulations and phantom experiments. Next, the method was evaluated for kidney and cardiac imaging in two separate healthy pigs.Results: Simulation and phantom results showed successful acquisition and reconstruction, but also revealed reconstruction challenges for certain locations and for wide signal sources. For the kidney experiment, the accelerated acquisition showed high similarity to two separately acquired fully sampled datasets with matched spatial and temporal resolution, respectively. For the kidney experiment, the accelerated acquisition proved able to map each metabolite in three dimensions within a single cardiac cycle.Conclusion: The proposed method demonstrated effective mapping of metabolism in both kidneys and heart of healthy pigs. Limitations seen in phantom experiments, may be irrelevant for most clinical applications, but should be kept in mind as well as reconstruction challenges related to residual aliasing. All in all, we show that the blipped-stack-of-spirals is a relevant parallel imaging method for hyperpolarized human imaging, facilitating better insights into metabolism compared to nonaccelerated acquisition.",
keywords = "Hyperpolarization, 13C MRI, Parallel Imaging, Metabolic imaging, 3D imaging",
author = "Olin, {Rie B.} and Sanchez, {Juan Diego} and Schulte, {Rolf F.} and Nikolaj B{\o}gh and {S{\o}vs{\o} Szocska Hansen}, Esben and Christoffer Laustsen and Hanson, {Lars G.} and Ardenkj{\ae}r-Larsen, {Jan H.}",
year = "2020",
language = "English",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",

}

Three-dimensional accelerated acquisition for hyperpolarized 13C MR with blipped stack-of-spirals and conjugate-gradient SENSE. / Olin, Rie B.; Sanchez, Juan Diego; Schulte, Rolf F.; Bøgh, Nikolaj; Søvsø Szocska Hansen, Esben; Laustsen, Christoffer; Hanson, Lars G. ; Ardenkjær-Larsen, Jan H.

In: Magnetic Resonance in Medicine, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Three-dimensional accelerated acquisition for hyperpolarized 13C MR with blipped stack-of-spirals and conjugate-gradient SENSE

AU - Olin, Rie B.

AU - Sanchez, Juan Diego

AU - Schulte, Rolf F.

AU - Bøgh, Nikolaj

AU - Søvsø Szocska Hansen, Esben

AU - Laustsen, Christoffer

AU - Hanson, Lars G.

AU - Ardenkjær-Larsen, Jan H.

PY - 2020

Y1 - 2020

N2 - Purpose: To test a new parallel imaging strategy for acceleration of hyperpolarized 13C MR acquisitions based on a 3D blipped-stack-of-spirals trajectory and conjugate gradient SENSE reconstruction with pre-calibrated sensitivities.Methods: The blipped-stack-of-spirals trajectory was developed for an acceleration factor of four, based on an undersampled stack-of-spirals with gradient blips during spiral readout. The trajectory was developed with volumetric coverage of a large FOV and with high spatial resolution. High temporal resolution was attained through spectral-spatial excitation and four excitations per volume. The blipped-stack-of-spirals was evaluated in simulations and phantom experiments. Next, the method was evaluated for kidney and cardiac imaging in two separate healthy pigs.Results: Simulation and phantom results showed successful acquisition and reconstruction, but also revealed reconstruction challenges for certain locations and for wide signal sources. For the kidney experiment, the accelerated acquisition showed high similarity to two separately acquired fully sampled datasets with matched spatial and temporal resolution, respectively. For the kidney experiment, the accelerated acquisition proved able to map each metabolite in three dimensions within a single cardiac cycle.Conclusion: The proposed method demonstrated effective mapping of metabolism in both kidneys and heart of healthy pigs. Limitations seen in phantom experiments, may be irrelevant for most clinical applications, but should be kept in mind as well as reconstruction challenges related to residual aliasing. All in all, we show that the blipped-stack-of-spirals is a relevant parallel imaging method for hyperpolarized human imaging, facilitating better insights into metabolism compared to nonaccelerated acquisition.

AB - Purpose: To test a new parallel imaging strategy for acceleration of hyperpolarized 13C MR acquisitions based on a 3D blipped-stack-of-spirals trajectory and conjugate gradient SENSE reconstruction with pre-calibrated sensitivities.Methods: The blipped-stack-of-spirals trajectory was developed for an acceleration factor of four, based on an undersampled stack-of-spirals with gradient blips during spiral readout. The trajectory was developed with volumetric coverage of a large FOV and with high spatial resolution. High temporal resolution was attained through spectral-spatial excitation and four excitations per volume. The blipped-stack-of-spirals was evaluated in simulations and phantom experiments. Next, the method was evaluated for kidney and cardiac imaging in two separate healthy pigs.Results: Simulation and phantom results showed successful acquisition and reconstruction, but also revealed reconstruction challenges for certain locations and for wide signal sources. For the kidney experiment, the accelerated acquisition showed high similarity to two separately acquired fully sampled datasets with matched spatial and temporal resolution, respectively. For the kidney experiment, the accelerated acquisition proved able to map each metabolite in three dimensions within a single cardiac cycle.Conclusion: The proposed method demonstrated effective mapping of metabolism in both kidneys and heart of healthy pigs. Limitations seen in phantom experiments, may be irrelevant for most clinical applications, but should be kept in mind as well as reconstruction challenges related to residual aliasing. All in all, we show that the blipped-stack-of-spirals is a relevant parallel imaging method for hyperpolarized human imaging, facilitating better insights into metabolism compared to nonaccelerated acquisition.

KW - Hyperpolarization

KW - 13C MRI

KW - Parallel Imaging

KW - Metabolic imaging

KW - 3D imaging

M3 - Journal article

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -