Thin-film Composite Biocatalytic Nanofibrous Membrane System for Pharmaceuticals’ Degradation: Performance, stability, and Continuity

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Recently, biocatalytic nanofibrous membranes have drawn attention in various fields such as biosensing and wastewater treatment because of their high specificity, prolonged reusability and low-cost efficiency. This study investigates a facile laccase-assisted nanofibrous filtration membrane system for transformation of pharmaceuticals. Laccases are successfully covalently immobilized on functionalized electrospun polyacrylonitile/β-cyclodextrin nanofibers. β-Cyclodextrin (β-CD), a cone-shape cyclic hepta-α-1,4-glucosyl compound, whose apolar cavity can encapsulate a variety of hydrophobic guest molecules. Intrestingly, β-CD offer a functional and spatial scaffold for enzyme immobilization. The catalytic kinetics parameters of both free and immobilized laccases are investigated. The immobilized enzyme shows a weaker affinity to the substrate but vastly improved stability compared to the free form, indicating that the immobilization elicits a considerable descrease in the rate of irreversible activation of the enzyme. The biocatalytic membrane can be reused and retains up to 90% of the initial activity after five cycles. Inspired by the improved stability, the enzymatic membranes combined with thin-film composite membrane are furthered investigated in a cross-flow filtration system to achieve a continuous and efficient removal of mefenamic acid. The removal of mefenamic acid could be maintained at 90%. Our findings demonstrate that laccase-assisted electrospun materials have the potential for application in environmental protection processes.
Original languageEnglish
Publication date2021
Number of pages1
Publication statusPublished - 2021
EventMembrane Desalination 2021: 5th International Conference on Desalination using Membrane Technology - Hybrid event, Shanghai, China
Duration: 14 Nov 202117 Nov 2021


ConferenceMembrane Desalination 2021
LocationHybrid event


  • Laccase
  • Electrospun fibrous membrane
  • Immobilization
  • Biodegradation


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