Thermally drawn biodegradable fibers with tailored topography for biomedical applications

Syamak Farajikhah*, Antoine F.J. Runge, Badwi B. Boumelhem, Ivan D. Rukhlenko, Alessio Stefani, Sepidar Sayyar, Peter C. Innis, Stuart T. Fraser, Simon Fleming, Maryanne C.J. Large

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

There is a growing demand for polymer fiber scaffolds for biomedical applications and tissue engineering. Biodegradable polymers such as polycaprolactone have attracted particular attention due to their applicability to tissue engineering and optical neural interfacing. Here we report on a scalable and inexpensive fiber fabrication technique, which enables the drawing of PCL fibers in a single process without the use of auxiliary cladding. We demonstrate the possibility of drawing PCL fibers of different geometries and cross-sections, including solid-core, hollow-core, and grooved fibers. The solid-core fibers of different geometries are shown to support cell growth, through successful MCF-7 breast cancer cell attachment and proliferation. We also show that the hollow-core fibers exhibit a relatively stable optical propagation loss after submersion into a biological fluid for up to 21 days with potential to be used as waveguides in optical neural interfacing. The capacity to tailor the surface morphology of biodegradable PCL fibers and their non-cytotoxicity make the proposed approach an attractive platform for biomedical applications and tissue engineering.

Original languageEnglish
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Number of pages11
ISSN1552-4973
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Biodegradable fibers
  • Cell cultures
  • PCL capillary waveguides
  • PCL fibers
  • Tailored cross-section
  • Thermally drawn fibers

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