The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish

Yaolei Zhang, Haoyang Gao, Hanbo Li, Jiao Guo, Bingjie Ouyang, Meiniang Wang, Qiwu Xu, Jiahao Wang, Meiqi Lv, Xinyu Guo, Qun Liu, Likun Wei, Han Ren, Yang Xi, Yang Guo, Bingzhao Ren, Shanshan Pan, Chuxin Liu, Xiaoyan Ding, Haitao XiangYingjia Yu, Yue Song, Lingfeng Meng, Shanshan Liu, Jun Wang, Yuan Jiang, Jiahai Shi, Shiping Liu, Jamal S. M. Sabir, Mumdooh J. Sabir, Muhummadh Khan, Nahid H. Hajrah, Simon Ming-Yuen Lee, Xun Xu, Huanming Yang, Jian Wang, Guangyi Fan*, Naibo Yang, Xin Liu

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Chondrichthyan (cartilaginous fish) occupies a key phylogenetic position and is important for investigating evolutionary processes of vertebrates. However, limited whole genomes impede our in-depth knowledge of important issues such as chromosome evolution and immunity. Here, we report the chromosome-level genome of white-spotted bamboo shark. Combing it with other shark genomes, we reconstructed 16 ancestral chromosomes of bamboo shark and illustrate a dynamic chromosome rearrangement process. We found that genes on 13 fast-evolving chromosomes can be enriched in immune-related pathways. And two chromosomes contain important genes that can be used to develop single-chain antibodies, which were shown to have high affinity to human disease markers by using enzyme-linked immunosorbent assay. We also found three bone formation-related genes were lost due to chromosome rearrangements. Our study highlights the importance of chromosome rearrangements, providing resources for understanding of cartilaginous fish diversification and potential application of single-chain antibodies.
Original languageEnglish
Article number101754
JournaliScience
Volume23
Issue number11
Number of pages10
ISSN2589-0042
DOIs
Publication statusPublished - 2020

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