The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

Cameron C. Weber; Samir A. Kulkarni; Andreas Jonas Kunov-Kruse; Robin D. Rogers; Allan S. Myerson

doi:10.1021/acs.cgd.5b00855

The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

Cameron C. Weber, Samir A. Kulkarni, Andreas Jonas Kunov-Kruse, Robin D. Rogers, Allan S. Myerson

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C₂C₁Im][NTf₂]) was studied as a potential cooling crystallization solvent for 12 active pharmaceutical ingredients (APIs), with 10 APIs being miscible with [C₂C₁Im][NTf2] around their melting point. Solubility curves were obtained for nine APIs, and the cooling crystallization of crude acetaminophen was conducted to show that [C₂C₁Im][NTf₂] represents a viable medium for the crystallization of APIs.

Original language	English
Journal	Crystal Growth & Design
Volume	15
Issue number	10
Pages (from-to)	4946-4951
Number of pages	6
ISSN	1528-7483
DOIs	https://doi.org/10.1021/acs.cgd.5b00855
Publication status	Published - 2015
Externally published	Yes

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title = "The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals",

abstract = "The ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C2C1Im][NTf2]) was studied as a potential cooling crystallization solvent for 12 active pharmaceutical ingredients (APIs), with 10 APIs being miscible with [C2C1Im][NTf2] around their melting point. Solubility curves were obtained for nine APIs, and the cooling crystallization of crude acetaminophen was conducted to show that [C2C1Im][NTf2] represents a viable medium for the crystallization of APIs.",

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year = "2015",

doi = "10.1021/acs.cgd.5b00855",

language = "English",

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T1 - The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

AU - Weber, Cameron C.

AU - Kulkarni, Samir A.

AU - Kunov-Kruse, Andreas Jonas

AU - Rogers, Robin D.

AU - Myerson, Allan S.

PY - 2015

Y1 - 2015

N2 - The ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C2C1Im][NTf2]) was studied as a potential cooling crystallization solvent for 12 active pharmaceutical ingredients (APIs), with 10 APIs being miscible with [C2C1Im][NTf2] around their melting point. Solubility curves were obtained for nine APIs, and the cooling crystallization of crude acetaminophen was conducted to show that [C2C1Im][NTf2] represents a viable medium for the crystallization of APIs.

AB - The ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C2C1Im][NTf2]) was studied as a potential cooling crystallization solvent for 12 active pharmaceutical ingredients (APIs), with 10 APIs being miscible with [C2C1Im][NTf2] around their melting point. Solubility curves were obtained for nine APIs, and the cooling crystallization of crude acetaminophen was conducted to show that [C2C1Im][NTf2] represents a viable medium for the crystallization of APIs.

U2 - 10.1021/acs.cgd.5b00855

DO - 10.1021/acs.cgd.5b00855

M3 - Journal article

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JO - Crystal Growth & Design

JF - Crystal Growth & Design

IS - 10

ER -

The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

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