The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals

Cameron C. Weber, Samir A. Kulkarni, Andreas Jonas Kunov-Kruse, Robin D. Rogers, Allan S. Myerson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C2C1Im][NTf2]) was studied as a potential cooling crystallization solvent for 12 active pharmaceutical ingredients (APIs), with 10 APIs being miscible with [C2C1Im][NTf2] around their melting point. Solubility curves were obtained for nine APIs, and the cooling crystallization of crude acetaminophen was conducted to show that [C2C1Im][NTf2] represents a viable medium for the crystallization of APIs.
Original languageEnglish
JournalCrystal Growth & Design
Volume15
Issue number10
Pages (from-to)4946-4951
Number of pages6
ISSN1528-7483
DOIs
Publication statusPublished - 2015
Externally publishedYes

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