The use of aptamers and molecularly imprinted polymers in biosensors for environmental monitoring: A tale of two receptors

Maryam Naseri, Mohsen Mohammadniaei, Yi Sun*, Jon Ashley*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Effective molecular recognition remains a major challenge in the development of robust receptors for biosensing applications. Over the last three decades, aptamers and molecularly imprinted polymers (MIPs) have emerged as the receptors of choice for use in biosensors as viable alternatives to natural antibodies, due to their superior stability, comparable binding performance, and lower costs. Although both of these technologies have been developed in parallel, they both suffer from their own unique problems. In this review, we will compare and contrast both types of receptor, with a focus on the area of environmental monitoring. Firstly, we will discuss the strategies and challenges involved in their development. We will also discuss the challenges that are involved in interfacing them with the biosensors. We will then compare and contrast their performance with a focus on their use in the detection of environmental contaminants, namely, antibiotics, pesticides, heavy metals, and pathogens detection. Finally, we will discuss the future direction of these two technologies.
Original languageEnglish
Article number32
JournalChemosensors
Volume8
Issue number2
Number of pages20
ISSN2227-9040
DOIs
Publication statusPublished - 2020

Keywords

  • Aptamer
  • Molecularly imprinted polymers
  • Environmental contaminants
  • Heavy metal
  • Pathogens
  • Antibiotics Elfamycin Genome sequence Kirromycin Streptomycetes

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