The search for the ideal biocatalyst

SG Burton; DA Cowan; John Woodley

doi:10.1038/nbt0102-37

The search for the ideal biocatalyst

SG Burton
, DA Cowan
, John Woodley

University College London

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

While the use of enzymes as biocatalysts to assist in the industrial manufacture of fine chemicals and pharmaceuticals has enormous potential, application is frequently limited by evolution-led catalyst traits. The advent of designer biocatalysts, produced by informed selection and mutation through recombinant DNA technology, enables production of process-compatible enzymes. However, to fully realize the potential of designer enzymes in industrial applications, it will be necessary to tailor catalyst properties so that they are optimal not only for a given reaction but also in the context of the industrial process in which the enzyme is applied.

Original language	English
Journal	Nature Biotechnology
Volume	20
Issue number	1
Pages (from-to)	37-45
ISSN	1087-0156
DOIs	https://doi.org/10.1038/nbt0102-37
Publication status	Published - 2002
Externally published	Yes

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title = "The search for the ideal biocatalyst",

abstract = "While the use of enzymes as biocatalysts to assist in the industrial manufacture of fine chemicals and pharmaceuticals has enormous potential, application is frequently limited by evolution-led catalyst traits. The advent of designer biocatalysts, produced by informed selection and mutation through recombinant DNA technology, enables production of process-compatible enzymes. However, to fully realize the potential of designer enzymes in industrial applications, it will be necessary to tailor catalyst properties so that they are optimal not only for a given reaction but also in the context of the industrial process in which the enzyme is applied. ",

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The search for the ideal biocatalyst

Abstract

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