The search for the ideal biocatalyst

SG Burton, DA Cowan, John Woodley

Research output: Contribution to journalJournal articleResearchpeer-review


While the use of enzymes as biocatalysts to assist in the industrial manufacture of fine chemicals and pharmaceuticals has enormous potential, application is frequently limited by evolution-led catalyst traits. The advent of designer biocatalysts, produced by informed selection and mutation through recombinant DNA technology, enables production of process-compatible enzymes. However, to fully realize the potential of designer enzymes in industrial applications, it will be necessary to tailor catalyst properties so that they are optimal not only for a given reaction but also in the context of the industrial process in which the enzyme is applied.
Original languageEnglish
JournalNature Biotechnology
Issue number1
Pages (from-to)37-45
Publication statusPublished - 2002
Externally publishedYes


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