The search for noise-induced cochlear synaptopathy in humans

Mission impossible?

Naomi Bramhall, Elizabeth Francis Beach, Bastian Epp, Colleen G. Le Prell, Enrique A. Lopez-Poveda, Christopher J. Plack, Roland Schaette, Sarah Verhulst, Barbara Canlon*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Animal studies demonstrate that noise exposure can permanently damage the synapses between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and there is no clinically relevant permanent threshold shift. Synaptopathy disrupts the afferent connection between the cochlea and the central auditory system and is predicted to impair speech understanding in noisy environments and potentially result in tinnitus and/or hyperacusis. While cochlear synaptopathy has been demonstrated in numerous experimental animal models, synaptopathy can only be confirmed through post-mortem temporal bone analysis, making it difficult to study in living humans. A variety of non-invasive measures have been used to determine whether noise-induced synaptopathy occurs in humans, but the results are conflicting. The overall objective of this article is to synthesize the existing data on the functional impact of noise-induced synaptopathy in the human auditory system. The first section of the article summarizes the studies that provide evidence for and against noise-induced synaptopathy in humans. The second section offers potential explanations for the differing results between studies. The final section outlines suggested methodologies for diagnosing synaptopathy in humans with the aim of improving consistency across studies.

Original languageEnglish
JournalHearing Research
Volume377
Pages (from-to)88-103
ISSN0378-5955
DOIs
Publication statusPublished - 2019

Cite this

Bramhall, N., Beach, E. F., Epp, B., Le Prell, C. G., Lopez-Poveda, E. A., Plack, C. J., ... Canlon, B. (2019). The search for noise-induced cochlear synaptopathy in humans: Mission impossible? Hearing Research, 377, 88-103. https://doi.org/10.1016/j.heares.2019.02.016
Bramhall, Naomi ; Beach, Elizabeth Francis ; Epp, Bastian ; Le Prell, Colleen G. ; Lopez-Poveda, Enrique A. ; Plack, Christopher J. ; Schaette, Roland ; Verhulst, Sarah ; Canlon, Barbara. / The search for noise-induced cochlear synaptopathy in humans : Mission impossible?. In: Hearing Research. 2019 ; Vol. 377. pp. 88-103.
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title = "The search for noise-induced cochlear synaptopathy in humans: Mission impossible?",
abstract = "Animal studies demonstrate that noise exposure can permanently damage the synapses between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and there is no clinically relevant permanent threshold shift. Synaptopathy disrupts the afferent connection between the cochlea and the central auditory system and is predicted to impair speech understanding in noisy environments and potentially result in tinnitus and/or hyperacusis. While cochlear synaptopathy has been demonstrated in numerous experimental animal models, synaptopathy can only be confirmed through post-mortem temporal bone analysis, making it difficult to study in living humans. A variety of non-invasive measures have been used to determine whether noise-induced synaptopathy occurs in humans, but the results are conflicting. The overall objective of this article is to synthesize the existing data on the functional impact of noise-induced synaptopathy in the human auditory system. The first section of the article summarizes the studies that provide evidence for and against noise-induced synaptopathy in humans. The second section offers potential explanations for the differing results between studies. The final section outlines suggested methodologies for diagnosing synaptopathy in humans with the aim of improving consistency across studies.",
author = "Naomi Bramhall and Beach, {Elizabeth Francis} and Bastian Epp and {Le Prell}, {Colleen G.} and Lopez-Poveda, {Enrique A.} and Plack, {Christopher J.} and Roland Schaette and Sarah Verhulst and Barbara Canlon",
year = "2019",
doi = "10.1016/j.heares.2019.02.016",
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Bramhall, N, Beach, EF, Epp, B, Le Prell, CG, Lopez-Poveda, EA, Plack, CJ, Schaette, R, Verhulst, S & Canlon, B 2019, 'The search for noise-induced cochlear synaptopathy in humans: Mission impossible?', Hearing Research, vol. 377, pp. 88-103. https://doi.org/10.1016/j.heares.2019.02.016

The search for noise-induced cochlear synaptopathy in humans : Mission impossible? / Bramhall, Naomi; Beach, Elizabeth Francis; Epp, Bastian; Le Prell, Colleen G.; Lopez-Poveda, Enrique A.; Plack, Christopher J.; Schaette, Roland; Verhulst, Sarah; Canlon, Barbara.

In: Hearing Research, Vol. 377, 2019, p. 88-103.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The search for noise-induced cochlear synaptopathy in humans

T2 - Mission impossible?

AU - Bramhall, Naomi

AU - Beach, Elizabeth Francis

AU - Epp, Bastian

AU - Le Prell, Colleen G.

AU - Lopez-Poveda, Enrique A.

AU - Plack, Christopher J.

AU - Schaette, Roland

AU - Verhulst, Sarah

AU - Canlon, Barbara

PY - 2019

Y1 - 2019

N2 - Animal studies demonstrate that noise exposure can permanently damage the synapses between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and there is no clinically relevant permanent threshold shift. Synaptopathy disrupts the afferent connection between the cochlea and the central auditory system and is predicted to impair speech understanding in noisy environments and potentially result in tinnitus and/or hyperacusis. While cochlear synaptopathy has been demonstrated in numerous experimental animal models, synaptopathy can only be confirmed through post-mortem temporal bone analysis, making it difficult to study in living humans. A variety of non-invasive measures have been used to determine whether noise-induced synaptopathy occurs in humans, but the results are conflicting. The overall objective of this article is to synthesize the existing data on the functional impact of noise-induced synaptopathy in the human auditory system. The first section of the article summarizes the studies that provide evidence for and against noise-induced synaptopathy in humans. The second section offers potential explanations for the differing results between studies. The final section outlines suggested methodologies for diagnosing synaptopathy in humans with the aim of improving consistency across studies.

AB - Animal studies demonstrate that noise exposure can permanently damage the synapses between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and there is no clinically relevant permanent threshold shift. Synaptopathy disrupts the afferent connection between the cochlea and the central auditory system and is predicted to impair speech understanding in noisy environments and potentially result in tinnitus and/or hyperacusis. While cochlear synaptopathy has been demonstrated in numerous experimental animal models, synaptopathy can only be confirmed through post-mortem temporal bone analysis, making it difficult to study in living humans. A variety of non-invasive measures have been used to determine whether noise-induced synaptopathy occurs in humans, but the results are conflicting. The overall objective of this article is to synthesize the existing data on the functional impact of noise-induced synaptopathy in the human auditory system. The first section of the article summarizes the studies that provide evidence for and against noise-induced synaptopathy in humans. The second section offers potential explanations for the differing results between studies. The final section outlines suggested methodologies for diagnosing synaptopathy in humans with the aim of improving consistency across studies.

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