The Sabatier principle as a tool for discovery and engineering of industrial enzymes

Jeppe Kari, Kay Schaller, Gustavo A. Molina, Kim Borch, Peter Westh*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The recent breakthrough in all-atom, protein structure prediction opens new avenues for a range of computational approaches in enzyme design. These new approaches could become instrumental for the development of technical biocatalysts, and hence our transition toward more sustainable industries. Here, we discuss one approach, which is well-known within inorganic catalysis, but essentially unexploited in biotechnology. Specifically, we review examples of linear free-energy relationships (LFERs) for enzyme reactions and discuss how LFERs and the associated Sabatier Principle may be implemented in algorithms that estimate kinetic parameters and enzyme performance based on model structures.
Original languageEnglish
Article number102843
JournalCurrent Opinion in Biotechnology
Volume78
Number of pages7
ISSN0958-1669
DOIs
Publication statusPublished - 2022

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