The role of the cerebral capillaries in acute ischemic stroke

Leif Østergaard, Sune Nørhøj Jespersen, Kim Mouridsen, Irene Klærke Mikkelsen, Kristjana Ýr Jonsdottír, Anna Tietze, Jakob Udby Blicher, Rasmus Aamand, Niels Hjort, Nina Kerting Iversen, Changsi Cai, Kristina Dupont Hougaard, Claus Z. Simonsen, Paul Von Weitzel-Mudersbach, Boris Modrau, Kartheeban Nagenthiraja, Lars Riisgaard Ribe, Mikkel Bo Hansen, Susanne Lise Bekke, Martin Gervais DahlmanJosep Puig, Salvador Pedraza, Joaquín Serena, Tae Hee Cho, Susanne Siemonsen, Götz Thomalla, Jens Fiehler, Norbert Nighoghossian, Grethe Andersen

Research output: Contribution to journalJournal articleResearchpeer-review


The pathophysiology of cerebral ischemia is traditionally understood in relation to reductions in cerebral blood flow (CBF). However, a recent reanalysis of the flow-diffusion equation shows that increased capillary transit time heterogeneity (CTTH) can reduce the oxygen extraction efficacy in brain tissue for a given CBF. Changes in capillary morphology are typical of conditions predisposing to stroke and of experimental ischemia. Changes in capillary flow patterns have been observed by direct microscopy in animal models of ischemia and by indirect methods in humans stroke, but their metabolic significance remain unclear. We modeled the effects of progressive increases in CTTH on the way in which brain tissue can secure sufficient oxygen to meet its metabolic needs. Our analysis predicts that as CTTH increases, CBF responses to functional activation and to vasodilators must be suppressed to maintain sufficient tissue oxygenation. Reductions in CBF, increases in CTTH, and combinations thereof can seemingly trigger a critical lack of oxygen in brain tissue, and the restoration of capillary perfusion patterns therefore appears to be crucial for the restoration of the tissue oxygenation after ischemic episodes. In this review, we discuss the possible implications of these findings for the prevention, diagnosis, and treatment of acute stroke.
Original languageEnglish
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
Pages (from-to)635-648
Number of pages14
Publication statusPublished - 2013
Externally publishedYes


  • acute ischemic stroke
  • capillary transit time heterogeneity (CTTH)
  • cerebrovascular reserve capacity (CVRC)
  • penumbra
  • reperfusion injury
  • stroke risk factors

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