The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells.

Mette Hemmingsen; Søren Vedel; Peder Skafte-Pedersen; David Sabourin; Philippe Collas; Henrik Bruus; Martin Dufva

doi:10.1371/journal.pone.0063638

The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells.

Mette Hemmingsen, Søren Vedel, Peder Skafte-Pedersen, David Sabourin, Philippe Collas, Henrik Bruus, Martin Dufva

University of Oslo

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Abstract

Using different cell densities and microfluidic perfusion cell cultures to suppress the effects of cell-released factors, we have demonstrated the significant role played by auto- or paracrine signaling in adipocyte differentiation. The cell-released factor(s) were shown to act in the recruitment phase of the differentiation process.

Original language	English
Article number	e63638
Journal	PloS one.
Volume	8
Issue number	5
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0063638
Publication status	Published - 2013

Bibliographical note

© 2013 Hemmingsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This work was supported by Grant No. 2106-08-0018 “ProCell” and grant no. 09-067112, under the Programme Commission on Strategic Growth Technologies, the Danish Agency for Science, Technology and Innovation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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title = "The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells.",

abstract = "Using different cell densities and microfluidic perfusion cell cultures to suppress the effects of cell-released factors, we have demonstrated the significant role played by auto- or paracrine signaling in adipocyte differentiation. The cell-released factor(s) were shown to act in the recruitment phase of the differentiation process. ",

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AU - Skafte-Pedersen, Peder

AU - Sabourin, David

AU - Collas, Philippe

AU - Bruus, Henrik

AU - Dufva, Martin

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AB - Using different cell densities and microfluidic perfusion cell cultures to suppress the effects of cell-released factors, we have demonstrated the significant role played by auto- or paracrine signaling in adipocyte differentiation. The cell-released factor(s) were shown to act in the recruitment phase of the differentiation process.

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The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells.

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