The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells.

Mette Hemmingsen, Søren Vedel, Peder Skafte-Pedersen, David Sabourin, Philippe Collas, Henrik Bruus, Martin Dufva

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Abstract

Using different cell densities and microfluidic perfusion cell cultures to suppress the effects of cell-released factors, we have demonstrated the significant role played by auto- or paracrine signaling in adipocyte differentiation. The cell-released factor(s) were shown to act in the recruitment phase of the differentiation process.
Original languageEnglish
Article numbere63638
JournalPloS one.
Volume8
Issue number5
ISSN1932-6203
DOIs
Publication statusPublished - 2013

Bibliographical note

© 2013 Hemmingsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This work was supported by Grant No. 2106-08-0018 “ProCell” and grant no. 09-067112, under the Programme Commission on Strategic Growth Technologies, the Danish Agency for Science, Technology and Innovation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Cite this

Hemmingsen, Mette ; Vedel, Søren ; Skafte-Pedersen, Peder ; Sabourin, David ; Collas, Philippe ; Bruus, Henrik ; Dufva, Martin. / The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells. In: PloS one. 2013 ; Vol. 8, No. 5.
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The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells. / Hemmingsen, Mette; Vedel, Søren; Skafte-Pedersen, Peder; Sabourin, David; Collas, Philippe; Bruus, Henrik; Dufva, Martin.

In: PloS one., Vol. 8, No. 5, e63638, 2013.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Sabourin, David

AU - Collas, Philippe

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