The Role of Functional Amyloids in Multicellular Growth and Development of Gram-Positive Bacteria

Anna Dragoš, Ákos T. Kovács, Dennis Claessen

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Abstract

Amyloid fibrils play pivotal roles in all domains of life. In bacteria, these fibrillar structures are often part of an extracellular matrix that surrounds the producing organism and thereby provides protection to harsh environmental conditions. Here, we discuss the role of amyloid fibrils in the two distant Gram-positive bacteria, Streptomyces coelicolor and Bacillus subtilis. We describe how amyloid fibrils contribute to a multitude of developmental processes in each of these systems, including multicellular growth and community development. Despite this variety of tasks, we know surprisingly little about how their assembly is organized to fulfill all these roles.
Original languageEnglish
Article number60
JournalBiomolecules
Volume7
Issue number3
Number of pages13
ISSN2218-273X
DOIs
Publication statusPublished - 2017

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Keywords

  • Bacillus subtilis
  • Streptomyces
  • TasA
  • Amyloid fiber
  • Biofilm
  • Chaplin
  • Development
  • Extracellular matrix
  • Multicellular growth

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