The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST

Kitty Verhoeckx*, Katrine Lindholm Bøgh, Didier Dupont, Lotti Egger, Gabriele Gadermaier, Colette Larré, Alan Mackie, Olivia Menard, Karine Adel-Patient, Gianluca Picariello, Reto Portmann, Joost Smit, Paul Turner, Eva Untersmayr, Michelle M. Epstein

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

97 Downloads (Pure)

Abstract

The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated that for in vitro protein digestibility tests, additional investigations are needed before any additional recommendation in the form of guidance can be provided. To this end, an interim phase is considered necessary to evaluate the revisions to the in vitro gastrointestinal digestion test, proposed by EFSA. This prompted the establishment of a joint workshop through two COST Action networks: COST Action ImpARAS and COST Acton INFOGEST. In 2017, a workshop was organised to discuss the relevance of digestion in allergenicity risk assessment and how to potentially improve the current methods and readouts. The outcome of the workshop is that there is no rationale for a clear readout that is predictive for allergenicity and we suggest to omit the digestion test from the allergenicity assessment strategy for now, and put an effort into filling the knowledge gaps as summarized in this paper first.

Original languageEnglish
JournalFood and Chemical Toxicology
Volume129
Pages (from-to)405-423
ISSN0278-6915
DOIs
Publication statusPublished - 2019

Keywords

  • Allergenicity risk assessment
  • Food allergy
  • Food digestion
  • In vitro protein digestibility tests
  • Novel proteins

Cite this

Verhoeckx, Kitty ; Bøgh, Katrine Lindholm ; Dupont, Didier ; Egger, Lotti ; Gadermaier, Gabriele ; Larré, Colette ; Mackie, Alan ; Menard, Olivia ; Adel-Patient, Karine ; Picariello, Gianluca ; Portmann, Reto ; Smit, Joost ; Turner, Paul ; Untersmayr, Eva ; Epstein, Michelle M. / The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST. In: Food and Chemical Toxicology. 2019 ; Vol. 129. pp. 405-423.
@article{1a9ad76256044da8a8b34cffd369395a,
title = "The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST",
abstract = "The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated that for in vitro protein digestibility tests, additional investigations are needed before any additional recommendation in the form of guidance can be provided. To this end, an interim phase is considered necessary to evaluate the revisions to the in vitro gastrointestinal digestion test, proposed by EFSA. This prompted the establishment of a joint workshop through two COST Action networks: COST Action ImpARAS and COST Acton INFOGEST. In 2017, a workshop was organised to discuss the relevance of digestion in allergenicity risk assessment and how to potentially improve the current methods and readouts. The outcome of the workshop is that there is no rationale for a clear readout that is predictive for allergenicity and we suggest to omit the digestion test from the allergenicity assessment strategy for now, and put an effort into filling the knowledge gaps as summarized in this paper first.",
keywords = "Allergenicity risk assessment, Food allergy, Food digestion, In vitro protein digestibility tests, Novel proteins",
author = "Kitty Verhoeckx and B{\o}gh, {Katrine Lindholm} and Didier Dupont and Lotti Egger and Gabriele Gadermaier and Colette Larr{\'e} and Alan Mackie and Olivia Menard and Karine Adel-Patient and Gianluca Picariello and Reto Portmann and Joost Smit and Paul Turner and Eva Untersmayr and Epstein, {Michelle M.}",
year = "2019",
doi = "10.1016/j.fct.2019.04.052",
language = "English",
volume = "129",
pages = "405--423",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",

}

Verhoeckx, K, Bøgh, KL, Dupont, D, Egger, L, Gadermaier, G, Larré, C, Mackie, A, Menard, O, Adel-Patient, K, Picariello, G, Portmann, R, Smit, J, Turner, P, Untersmayr, E & Epstein, MM 2019, 'The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST', Food and Chemical Toxicology, vol. 129, pp. 405-423. https://doi.org/10.1016/j.fct.2019.04.052

The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST. / Verhoeckx, Kitty; Bøgh, Katrine Lindholm; Dupont, Didier; Egger, Lotti; Gadermaier, Gabriele; Larré, Colette; Mackie, Alan; Menard, Olivia; Adel-Patient, Karine; Picariello, Gianluca; Portmann, Reto; Smit, Joost; Turner, Paul; Untersmayr, Eva; Epstein, Michelle M.

In: Food and Chemical Toxicology, Vol. 129, 2019, p. 405-423.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST

AU - Verhoeckx, Kitty

AU - Bøgh, Katrine Lindholm

AU - Dupont, Didier

AU - Egger, Lotti

AU - Gadermaier, Gabriele

AU - Larré, Colette

AU - Mackie, Alan

AU - Menard, Olivia

AU - Adel-Patient, Karine

AU - Picariello, Gianluca

AU - Portmann, Reto

AU - Smit, Joost

AU - Turner, Paul

AU - Untersmayr, Eva

AU - Epstein, Michelle M.

PY - 2019

Y1 - 2019

N2 - The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated that for in vitro protein digestibility tests, additional investigations are needed before any additional recommendation in the form of guidance can be provided. To this end, an interim phase is considered necessary to evaluate the revisions to the in vitro gastrointestinal digestion test, proposed by EFSA. This prompted the establishment of a joint workshop through two COST Action networks: COST Action ImpARAS and COST Acton INFOGEST. In 2017, a workshop was organised to discuss the relevance of digestion in allergenicity risk assessment and how to potentially improve the current methods and readouts. The outcome of the workshop is that there is no rationale for a clear readout that is predictive for allergenicity and we suggest to omit the digestion test from the allergenicity assessment strategy for now, and put an effort into filling the knowledge gaps as summarized in this paper first.

AB - The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated that for in vitro protein digestibility tests, additional investigations are needed before any additional recommendation in the form of guidance can be provided. To this end, an interim phase is considered necessary to evaluate the revisions to the in vitro gastrointestinal digestion test, proposed by EFSA. This prompted the establishment of a joint workshop through two COST Action networks: COST Action ImpARAS and COST Acton INFOGEST. In 2017, a workshop was organised to discuss the relevance of digestion in allergenicity risk assessment and how to potentially improve the current methods and readouts. The outcome of the workshop is that there is no rationale for a clear readout that is predictive for allergenicity and we suggest to omit the digestion test from the allergenicity assessment strategy for now, and put an effort into filling the knowledge gaps as summarized in this paper first.

KW - Allergenicity risk assessment

KW - Food allergy

KW - Food digestion

KW - In vitro protein digestibility tests

KW - Novel proteins

U2 - 10.1016/j.fct.2019.04.052

DO - 10.1016/j.fct.2019.04.052

M3 - Journal article

VL - 129

SP - 405

EP - 423

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -